Assessment of acute and chronic changes in parathyroid hormone secretion by a radioimmunoassay with predominant specificity for the carboxy-terminal region of the molecule

Jacqueline G. Parthemore, Bernard A. Roos, Donal C. Parker, Daniel F. Kripke, Louis V. Avioli, Leonard J. Deftos

Research output: Contribution to journalArticle

22 Scopus citations


A sensitive RIA for parathyroid hormone (PTH) with specificity for the carboxy-terminal region of the hormone was developed and applied to clinical studies. The assay was useful in identifying patients with chronic hyperparathyroid states, such as primary and secondary hyperparathyroidism. In addition, the assay could detect acute changes in PTH seen during calcium, pentagastrin, and EDTA infusions and after parathyroidectomy. These studies demonstrated that an immunoassay with predominant specificity for the carboxy-terminal fragment of PTH can be used to evaluate acute as well as chronic changes in hormone secretion.

Original languageEnglish (US)
Pages (from-to)284-289
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Issue number2
StatePublished - Aug 1978


ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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