Assessment of acute and chronic changes in parathyroid hormone secretion by a radioimmunoassay with predominant specificity for the carboxy-terminal region of the molecule

J. G. Parthemore, B. A. Roos, D. C. Parker, D. F. Kripke, L. V. Avioli, L. J. Deftos

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A sensitive RIA for parathyroid hormone (PTH) with specificity for the carboxy-terminal region of the hormone was developed and applied to clinical studies. The assay was useful in identifying patients with chronic hyperparathyroid states, such as primary and secondary hyperparathyroidism. In addition, the assay could detect acute changes in PTH seen during calcium, pentagastrin, and EDTA infusions and after parathyroidectomy. These studies demonstrated that an immunoassay with predominant specificity for the carboxy-terminal fragment of PTH can be used to evaluate acute as well as chronic changes in hormone secretion.

Original languageEnglish
Pages (from-to)284-289
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume47
Issue number2
StatePublished - Dec 1 1978
Externally publishedYes

Fingerprint

Parathyroid Hormone
Radioimmunoassay
Hormones
Pentagastrin
Parathyroidectomy
Secondary Hyperparathyroidism
Molecules
Primary Hyperparathyroidism
Assays
Immunoassay
Edetic Acid
Calcium
carboxyl-terminal parathyroid hormone
Clinical Studies

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Assessment of acute and chronic changes in parathyroid hormone secretion by a radioimmunoassay with predominant specificity for the carboxy-terminal region of the molecule. / Parthemore, J. G.; Roos, B. A.; Parker, D. C.; Kripke, D. F.; Avioli, L. V.; Deftos, L. J.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 47, No. 2, 01.12.1978, p. 284-289.

Research output: Contribution to journalArticle

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