Assessment of 3D proton MR echo-planar spectroscopic imaging using automated spectral analysis

Andreas Ebel, Brian J. Soher, Andrew A. Maudsley

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


For many clinical applications of proton MR spectroscopic imaging (MRSI) of the brain, diagnostic assessment is limited by insufficient coverage provided by single- or multislice acquisition methods as well as by the use of volume preselection methods. Additionally, traditional spectral analysis methods may limit the operator to detailed analysis of only a few selected brain regions. It is therefore highly desirable to use a fully 3D approach, combined with spectral analysis procedures that enable automated assessment of 3D metabolite distributions over the whole brain. In this study, a 3D echo-planar MRSI technique has been implemented without volume preselection to provide sufficient spatial resolution with maximum coverage of the brain. Using MRSI acquisitions in normal subjects at 1.5T and a fully automated spectral analysis procedure, an assessment of the resultant spectral quality and the extent of viable data in human brain was carried out. The analysis found that 69% of brain voxels were obtained with acceptable spectral quality at TE = 135 ms, and 52% at TE = 25 ms. Most of the rejected voxels were located near the sinuses or temporal bones and demonstrated poor Bo homogeneity and additional regions were affected by stronger lipid contamination at TE = 25 ms.

Original languageEnglish (US)
Pages (from-to)1072-1078
Number of pages7
JournalMagnetic Resonance in Medicine
Issue number6
StatePublished - 2001
Externally publishedYes


  • 3D
  • Automated spectral analysis
  • Human brain
  • MRSI
  • Proton NMR spectroscopic imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology


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