Abstract
For many clinical applications of proton MR spectroscopic imaging (MRSI) of the brain, diagnostic assessment is limited by insufficient coverage provided by single- or multislice acquisition methods as well as by the use of volume preselection methods. Additionally, traditional spectral analysis methods may limit the operator to detailed analysis of only a few selected brain regions. It is therefore highly desirable to use a fully 3D approach, combined with spectral analysis procedures that enable automated assessment of 3D metabolite distributions over the whole brain. In this study, a 3D echo-planar MRSI technique has been implemented without volume preselection to provide sufficient spatial resolution with maximum coverage of the brain. Using MRSI acquisitions in normal subjects at 1.5T and a fully automated spectral analysis procedure, an assessment of the resultant spectral quality and the extent of viable data in human brain was carried out. The analysis found that 69% of brain voxels were obtained with acceptable spectral quality at TE = 135 ms, and 52% at TE = 25 ms. Most of the rejected voxels were located near the sinuses or temporal bones and demonstrated poor Bo homogeneity and additional regions were affected by stronger lipid contamination at TE = 25 ms.
| Original language | English |
|---|---|
| Pages (from-to) | 1072-1078 |
| Number of pages | 7 |
| Journal | Magnetic Resonance in Medicine |
| Volume | 46 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 12 2001 |
| Externally published | Yes |
Fingerprint
Keywords
- 3D
- Automated spectral analysis
- Human brain
- MRSI
- Proton NMR spectroscopic imaging
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Assessment of 3D proton MR echo-planar spectroscopic imaging using automated spectral analysis. / Ebel, Andreas; Soher, Brian J.; Maudsley, Andrew A.
In: Magnetic Resonance in Medicine, Vol. 46, No. 6, 12.12.2001, p. 1072-1078.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Assessment of 3D proton MR echo-planar spectroscopic imaging using automated spectral analysis
AU - Ebel, Andreas
AU - Soher, Brian J.
AU - Maudsley, Andrew A
PY - 2001/12/12
Y1 - 2001/12/12
N2 - For many clinical applications of proton MR spectroscopic imaging (MRSI) of the brain, diagnostic assessment is limited by insufficient coverage provided by single- or multislice acquisition methods as well as by the use of volume preselection methods. Additionally, traditional spectral analysis methods may limit the operator to detailed analysis of only a few selected brain regions. It is therefore highly desirable to use a fully 3D approach, combined with spectral analysis procedures that enable automated assessment of 3D metabolite distributions over the whole brain. In this study, a 3D echo-planar MRSI technique has been implemented without volume preselection to provide sufficient spatial resolution with maximum coverage of the brain. Using MRSI acquisitions in normal subjects at 1.5T and a fully automated spectral analysis procedure, an assessment of the resultant spectral quality and the extent of viable data in human brain was carried out. The analysis found that 69% of brain voxels were obtained with acceptable spectral quality at TE = 135 ms, and 52% at TE = 25 ms. Most of the rejected voxels were located near the sinuses or temporal bones and demonstrated poor Bo homogeneity and additional regions were affected by stronger lipid contamination at TE = 25 ms.
AB - For many clinical applications of proton MR spectroscopic imaging (MRSI) of the brain, diagnostic assessment is limited by insufficient coverage provided by single- or multislice acquisition methods as well as by the use of volume preselection methods. Additionally, traditional spectral analysis methods may limit the operator to detailed analysis of only a few selected brain regions. It is therefore highly desirable to use a fully 3D approach, combined with spectral analysis procedures that enable automated assessment of 3D metabolite distributions over the whole brain. In this study, a 3D echo-planar MRSI technique has been implemented without volume preselection to provide sufficient spatial resolution with maximum coverage of the brain. Using MRSI acquisitions in normal subjects at 1.5T and a fully automated spectral analysis procedure, an assessment of the resultant spectral quality and the extent of viable data in human brain was carried out. The analysis found that 69% of brain voxels were obtained with acceptable spectral quality at TE = 135 ms, and 52% at TE = 25 ms. Most of the rejected voxels were located near the sinuses or temporal bones and demonstrated poor Bo homogeneity and additional regions were affected by stronger lipid contamination at TE = 25 ms.
KW - 3D
KW - Automated spectral analysis
KW - Human brain
KW - MRSI
KW - Proton NMR spectroscopic imaging
UR - http://www.scopus.com/inward/record.url?scp=0035190136&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035190136&partnerID=8YFLogxK
U2 - 10.1002/mrm.1301
DO - 10.1002/mrm.1301
M3 - Article
C2 - 11746571
AN - SCOPUS:0035190136
VL - 46
SP - 1072
EP - 1078
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
SN - 0740-3194
IS - 6
ER -