Assessing the mechanical properties of tissue-mimicking phantoms at different depths as an approach to measure biomechanical gradient of crystalline lens

Shang Wang, Salavat Aglyamov, Andrei Karpiouk, Jiasong Li, Stanislav Emelianov, Fabrice Manns, Kirill V. Larin

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We demonstrate the feasibility of using the dominant frequency of the sample surface response to a mechanical stimulation as an effective indicator for sensing the depth wise distribution of elastic properties in transparent layered phantom samples simulating the cortex and nucleus of the crystalline lens. Focused ultrasound waves are used to non invasively interrogate the sample surface. A phase-sensitive optical coherence tomography system is utilized to capture the surface dynamics over time with nanometer scale sensitivity. Spectral analysis is performed on the sample surface response to ultrasound stimulation and the dominant frequency is calculated under particular loading parameters. Pilot experiments were conducted on homogeneous and layered tissue-mimicking phantoms. Results indicate that the mechanical layers located at different depths introduce different frequencies to the sample surface response, which are correlated with the depth-dependent elasticity of the sample. The duration and the frequency of the ultrasound excitation are also investigated for their influences on this spectrum-based detection. This noninvasive method may be potentially applied for localized and rapid assessment of the depth dependence of the mechanical properties of the crystalline lens.

Original languageEnglish
Pages (from-to)2769-2780
Number of pages12
JournalBiomedical Optics Express
Volume4
Issue number12
DOIs
StatePublished - Dec 1 2013

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Crystalline Lens Cortex
Crystalline Lens Nucleus
Crystalline Lens
Elasticity
Optical Coherence Tomography
lenses
mechanical properties
gradients
stimulation
elastic properties
cortexes
spectrum analysis
Ultrasonic Waves
tomography

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

Cite this

Assessing the mechanical properties of tissue-mimicking phantoms at different depths as an approach to measure biomechanical gradient of crystalline lens. / Wang, Shang; Aglyamov, Salavat; Karpiouk, Andrei; Li, Jiasong; Emelianov, Stanislav; Manns, Fabrice; Larin, Kirill V.

In: Biomedical Optics Express, Vol. 4, No. 12, 01.12.2013, p. 2769-2780.

Research output: Contribution to journalArticle

Wang, Shang ; Aglyamov, Salavat ; Karpiouk, Andrei ; Li, Jiasong ; Emelianov, Stanislav ; Manns, Fabrice ; Larin, Kirill V. / Assessing the mechanical properties of tissue-mimicking phantoms at different depths as an approach to measure biomechanical gradient of crystalline lens. In: Biomedical Optics Express. 2013 ; Vol. 4, No. 12. pp. 2769-2780.
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