Assessing anticoagulation practice patterns in patients on durable mechanical circulatory support devices: An international survey

Douglas L. Jennings, Edward T. Horn, Haifa Lyster, Anthony L. Panos, Jeffrey J. Teuteberg, Hans B. Lehmkuhl, Alexandra Perez, Michael A. Shullo

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Anticoagulation in mechanical circulatory support (MCS) patients dictated by local practice, and therefore uniform standards for management are lacking. To characterize the worldwide variance in anticoagulation and antiplatelet therapy in patients with MCS devices, a 42 item survey was created and distributed electronically in August 2014. The survey assessed the center-perceived thromboembolic risk (minimal, low, moderate, or high) and characterized the antiplatelet and anticoagulant strategies for the Thoratec HeartMate II (HMII) and HeartWare HVAD (HVAD). A total of 83/214 centers (39%) responded: North America (60/152), Europe (18/50), Australia (2/4), and Asia (3/8). Although the most common target international normalized ratio (INR) was 2-3 for both devices, significant variability exists. Anticoagulation intensity tended to be lower with the HMII, with more centers targeting INR values of less than 2.5. Aspirin monotherapy was the most common antiplatelet regimen; however, the HVAD patients were more likely to be on daily aspirin doses over 100 mg. In addition, parenteral bridging was more frequent with the HVAD device. While 43.8% of respondents indicated an increase in the perceived risk of HMII device thrombosis in 2014, intensification of anticoagulation (22%) or antiplatelet (11%) therapy was infrequent. Our findings verify the wide variety of anticoagulation practice patterns between MCS centers.

Original languageEnglish (US)
Pages (from-to)28-32
Number of pages5
JournalASAIO Journal
Volume62
Issue number1
DOIs
StatePublished - Jan 1 2016

Keywords

  • Anticoagulation
  • Device Thrombosis
  • Mechanical Circulatory Support
  • Practice Variance
  • Stroke

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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    Jennings, D. L., Horn, E. T., Lyster, H., Panos, A. L., Teuteberg, J. J., Lehmkuhl, H. B., Perez, A., & Shullo, M. A. (2016). Assessing anticoagulation practice patterns in patients on durable mechanical circulatory support devices: An international survey. ASAIO Journal, 62(1), 28-32. https://doi.org/10.1097/MAT.0000000000000274