Assessement of serum amyloid a levels in the rehabilitation setting in the florida manatee (trichechus manatus latirostris)

Carolyn Cray, Maya Rodriguez, Meranda Dickey, Leah Brinson Brewer, Kristopher L. Arheart

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


The acute phase protein serum amyloid A (SAA) has been previously shown to have value as a biomarker of inflammation and infection in many species, including manatees (Trichechus manatus latirostris). In the current study, results from an automated assay for SAA were used in a rehabilitation setting. Reference intervals were established from clinically normal manatees using the robust method: 0-46 mg/L. More than 30-fold higher mean SAA levels were observed in manatees suffering from cold stress and boat-related trauma. Poor correlations were observed between SAA and total white blood count, percentage of neutrophils, albumin, and albumin/globulin ratio. A moderate correlation was observed between SAA and the presence of nucleated red blood cells. The sensitivity of SAA testing was 93% and the specificity was 98%, representing the highest combined values of all the analytes. The results indicate that the automated method for SAA quantitation can provide important clinical data for manatees in a rehabilitation setting.

Original languageEnglish (US)
Pages (from-to)911-917
Number of pages7
JournalJournal of Zoo and Wildlife Medicine
Issue number4
StatePublished - Dec 1 2013


  • Trichechus manatus latirostris.

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)


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