Assembling an orchestra: Fanconi anemia pathway of DNA repair

Fenghua Yuan, Limin Song, Liangyue Qian, Jennifer J. Hu, Yanbin Zhang

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Fanconi anemia (FA) is a recessive genetic disorder characterized by developmental defects, bone marrow failure, and cancer susceptibility. The complete set of FA genes has only been identified recently and seems to be uniquely conserved among vertebrates. Fanconi anemia proteins have been implicated in the repair of interstrand DNA crosslinks that block DNA replication and transcription. Although all thirteen FA complementation groups show similar clinical and cellular phenotypes, approximately 85% of patients presented defective FANCA, FANCC, or FANCG. The established DNA interacting components (FANCM, FANCI, FANCD2, and FANCJ) account only for ~5% of all FA patients, an observation that raises doubt concerning the roles of FA proteins in DNA repair. In recent years, rapid progress in the area of FA research has provided great insights into the critical roles of FA proteins in DNA repair. However, many FA proteins do not have identifiable domains to indicate how they contribute to biological processes, particularly DNA repair. Therefore, future biochemical studies are warranted to understand the biological functions of FA proteins and their implications in human diseases.

Original languageEnglish (US)
Pages (from-to)1131-1149
Number of pages19
JournalFrontiers in Bioscience
Volume15
Issue number3
StatePublished - Jun 1 2010

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Keywords

  • Cancer
  • Dna repair
  • Fanconi anemia
  • Homologous recombination
  • Icl incision
  • Interstrand crosslink
  • Replication
  • Review
  • Translesion synthesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

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