Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery

Nathan P. Coussens, G. Sitta Sittampalam, Rajarshi Guha, Kyle Brimacombe, Abigail Grossman, Thomas D.Y. Chung, Jeffrey R. Weidner, Terry Riss, O. Joseph Trask, Douglas Auld, Jayme L. Dahlin, Viswanath Devanaryan, Timothy L. Foley, James McGee, Steven D. Kahl, Stephen C. Kales, Michelle Arkin, Jonathan Baell, Bruce Bejcek, Neely Gal-EddMarcie Glicksman, Joseph V. Haas, Philip W. Iversen, Marilu Hoeppner, Stacy Lathrop, Eric Sayers, Hanguan Liu, Bart Trawick, Julie McVey, Vance P. Lemmon, Zhuyin Li, Owen McManus, Lisa Minor, Andrew Napper, Mary Jo Wildey, Robert Pacifici, William W. Chin, Menghang Xia, Xin Xu, Madhu Lal-Nag, Matthew D. Hall, Sam Michael, James Inglese, Anton Simeonov, Christopher P. Austin

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The Assay Guidance Manual (AGM) is an eBook of best practices for the design, development, and implementation of robust assays for early drug discovery. Initiated by pharmaceutical company scientists, the manual provides guidance for designing a “testing funnel” of assays to identify genuine hits using high-throughput screening (HTS) and advancing them through preclinical development. Combined with a workshop/tutorial component, the overall goal of the AGM is to provide a valuable resource for training translational scientists.

Original languageEnglish (US)
Pages (from-to)461-470
Number of pages10
JournalClinical and Translational Science
Volume11
Issue number5
DOIs
StatePublished - Sep 2018

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Coussens, N. P., Sittampalam, G. S., Guha, R., Brimacombe, K., Grossman, A., Chung, T. D. Y., Weidner, J. R., Riss, T., Trask, O. J., Auld, D., Dahlin, J. L., Devanaryan, V., Foley, T. L., McGee, J., Kahl, S. D., Kales, S. C., Arkin, M., Baell, J., Bejcek, B., ... Austin, C. P. (2018). Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery. Clinical and Translational Science, 11(5), 461-470. https://doi.org/10.1111/cts.12570