@article{dd0ffd7650754be58f870a4b20ecf9ae,
title = "Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery",
abstract = "The Assay Guidance Manual (AGM) is an eBook of best practices for the design, development, and implementation of robust assays for early drug discovery. Initiated by pharmaceutical company scientists, the manual provides guidance for designing a “testing funnel” of assays to identify genuine hits using high-throughput screening (HTS) and advancing them through preclinical development. Combined with a workshop/tutorial component, the overall goal of the AGM is to provide a valuable resource for training translational scientists.",
author = "Coussens, {Nathan P.} and Sittampalam, {G. Sitta} and Rajarshi Guha and Kyle Brimacombe and Abigail Grossman and Chung, {Thomas D.Y.} and Weidner, {Jeffrey R.} and Terry Riss and Trask, {O. Joseph} and Douglas Auld and Dahlin, {Jayme L.} and Viswanath Devanaryan and Foley, {Timothy L.} and James McGee and Kahl, {Steven D.} and Kales, {Stephen C.} and Michelle Arkin and Jonathan Baell and Bruce Bejcek and Neely Gal-Edd and Marcie Glicksman and Haas, {Joseph V.} and Iversen, {Philip W.} and Marilu Hoeppner and Stacy Lathrop and Eric Sayers and Hanguan Liu and Bart Trawick and Julie McVey and Lemmon, {Vance P.} and Zhuyin Li and Owen McManus and Lisa Minor and Andrew Napper and Wildey, {Mary Jo} and Robert Pacifici and Chin, {William W.} and Menghang Xia and Xin Xu and Madhu Lal-Nag and Hall, {Matthew D.} and Sam Michael and James Inglese and Anton Simeonov and Austin, {Christopher P.}",
note = "Funding Information: The authors thank Jeff Beck, Charles ?Pepper? Bonney, Penny Burgoon, Laura Carter, Nolan Chase, Adrian Choice, Neal Cosby, Janice Crum, Suzanne C. Fitzpatrick, Nicholas Gelardi, C. Taylor Gilliland, Sam Grammer, Steven Hamilton, David Hanley, Nicole Haselwander, Michael Hoffmann, Sandy Ismail, Anne Ketter, Ann Knebel, Emet LaBoone, Theresa Lamotte, A. Renee Madden, Cindy McConnell, Dave Morris, Henrike Nelsen, Jim Ostell, Kim Pruitt, Melvin Reichman, Laura Richards, Meghan Schofield, Hannah Scott, Stephanie Shea, Geoff Spencer, Ashley Stewart, Amy Wilkinson, and Adam Yasgar for their support of the AGM. This work was supported by the NCATS Division of Pre-Clinical Innovation Intramural Program and by the Intramural Research Program of the NIH, National Library of Medicine. Authors also acknowledge the NIGMS R13 grant support (5U13MH088095-02) for the annual editor's conference on Development of Robust Experimental Assay Methods (aDREAM) from 2011?2014. Funding Information: Source of Funding. This work was supported by the NCATS Division of Pre-Clinical Innovation Intramural Program and by the Intramural Research Program of the NIH, National Library of Medicine. Authors also acknowledge the NIGMS R13 grant support (5U13MH088095-02) for the annual editor{\textquoteright}s conference on Development of Robust Experimental Assay Methods (aDREAM) from 2011–2014. Publisher Copyright: {\textcopyright} 2018 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of the American Society of Clinical Pharmacology and Therapeutics",
year = "2018",
month = sep,
doi = "10.1111/cts.12570",
language = "English (US)",
volume = "11",
pages = "461--470",
journal = "Clinical and Translational Science",
issn = "1752-8054",
publisher = "Wiley-Blackwell",
number = "5",
}