Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine

Emily A. Minor, Brenda L. Court, Juan I. Young, Gaofeng Wang

Research output: Contribution to journalArticlepeer-review

210 Scopus citations

Abstract

Background: Tet methylcytosine dioxygenase converts 5-mC to 5-hmC in DNA. Results: Ascorbate significantly and specifically enhances Tet-mediated generation of 5-hmC. Conclusion: Our findings suggest that ascorbate enhances 5-hmC generation, most likely by acting as a co-factor for Tet methylcytosine dioxygenase to generate 5-hmC. Significance: The availability of ascorbate could have significant consequences for health and diseases by modulating the epigenetic control of genome activity.

Original languageEnglish (US)
Pages (from-to)13669-13674
Number of pages6
JournalJournal of Biological Chemistry
Volume288
Issue number19
DOIs
StatePublished - May 10 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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