Arylsulfatase activity in human urine: quantitative studies on patients with lysosomal disorders including metachromatic leukodystrophy

G. H. Thomas, R. R. Howell

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

A rapid and simple quantitative assay has been employed to measure the arylsulfatase A activity in urine samples from 173 individuals. This group includes three patients with late infantile metachromatic leukodystrophy (MLD), three patients with the adult form of metachromatic leukodystrophy, seven patients with other lysosomal disorders, and a control group. The average urinary arylsulfatase A activity of the MLD patients was 3.4% of the average activity found in the control group. In marked contrast, the arylsulfatase for the seven patients with other lysosomal disorders was found to be elevated in most of the urine samples tested.

Original languageEnglish (US)
Pages (from-to)99-103
Number of pages5
JournalClinica Chimica Acta
Volume36
Issue number1
DOIs
StatePublished - Jan 1972
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

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