Artificial meshwork (MESH) clinical and histological study in the rabbit with a six months follow up

P. Helies, M. Savoldelli, J. M. Legeais, J. M. Parel, G. J. Renard

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Purpose to study a new filtering surgery with an artificial meshwork and the role of adjunctive antimitotic drugs on the behavior of IOP and filtering blebs. Methods : an artificial meshwork (MESH) made of expanded polytetrafluoroethylene (ePTFE) with a pore size of about 5u was used 10 reduce IOP. Surgery was performed in 24 pigmented rabbits on the right eye, the left eye being used as control. The animals were randomly distributed in 3 groups of 8 rabbits, the first one being operated with MESH alone, the second with MESH + topical application of Mitomycin C, and the third one with MESH + a CDRi of 5 Fluorouracil. Follow-up was 6 months with a weekly examination including slit lamp observation and photography , bleb assessment and IOP readings on both eyes under topical anesthesia. Histology was performed at 1, 2, 3, 4 and 6 months after surgery. Results during the 6 months follow up the IOP was lower in the operated eye as compared to the fellow eye The difference was statistically significant (p<0.01) at week 5. The filtering blebs survived for 6 months The tolerance was good with no rejection of the artificial meshwork The antimitotic drugs improved the results in terms of reducing IOP, the differences being statistically significant at weeks 1, 2, 4, 9, 17 and 23. Histologically the implant was well tolerated. There was a moderate cellular ingrowth in the passage through the sciera but no cellular ingrowth in the anterior chamber There was no evidence of encapsulation or extrusion. Conclusion this surgery is simple, less invasive than trabeculectomy and requires less surgical time. The material is well tolerated, clinically and histologically. The MESH seems suitable for the surgical treatment of glaucoma.

Original languageEnglish (US)
Pages (from-to)S269
JournalInvestigative Ophthalmology and Visual Science
Volume38
Issue number4
StatePublished - Dec 1 1997
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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