Artificial meshwork implant (MESH) for glaucoma filtration surgery

H. Kato, J. M. Parel, V. Jallet, T. Matsui, H. Kondo, W. Lee, D. Budenz, G. Renard, Y. Pouliquen

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Purpose. To investigate safety and efficacy of a novel glaucoma filtering implant. Methods. A T shaped PTFE implant with 10μm pores (IOVS 36(4):S412, S346, 1995) was inserted subconjunctivally through a 3.2mm paracentesis in 17 rabbits. Biocompatibility, IOP (Goldmann applanation), and aqueous outflow (Schiötz) were weekly assessed in both the operated and contralateral eyes and compared with a sham surgery group of 6 animals. To determine the aqueous pathway, sham implants made of non-porous PTFE were implanted in 6 other animals. Results. No extrusion occurred and no foreign body reaction was found histologically. IOP decreased -29.5±6.78% at POD28, -22.4±9.54% at POD84 compared to the controlateral unoperated eyes. Significant differences in IOP decrease were found until POD91 (P<0.05). The ratio of aqueous outflow (operated/controlateral) was +1.9±0.31 at POD28, +1.6±0.21 at POD84. Significant differences of outflow ratio were found until POD84 (P<0.05). In the sham surgery group (no implant), significant differences of IOP decrease and outflow increase were found until POD3 (P<0.05). With the sham implant, significant differences of IOP decrease were found until POD14 (P<0.05) and outflow increase until POD 7 (P<0.05). Conclusion. The MESH is a biocompatible and efficacious filtration implant that might be effective for the treatment of glaucoma patients.

Original languageEnglish (US)
Pages (from-to)S256
JournalInvestigative Ophthalmology and Visual Science
Volume37
Issue number3
StatePublished - Feb 15 1996

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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