Artificial cornea: cellular ingrowth and transparency of an expanded polytetrafluoroethylene

Jean Marc M.D. Legeais, Gilles Renard, Jean Marie Parel, Gabriel M.D. Simon, Yves Pouliquen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

The development of a matrix with high cell adhesion and ingrowth rates is of importance for artificial cornea. The design of such artificial matrices requires understanding of cellular system colonization processes. After lamellar implementation the more impermeable the material, the larger the diameter and the more anterior placement, the more likely it is that the anterior stroma will starve and become necrotic. One approach to this problem is fenestration or open porosity of the material. Modifications in the thickness, pore size, and their geometric orientation of an expanded polytetrafluorethylene could modify the cellular ingrowth rate. Immunohistochemical study with the monoclonal antibodies AE5 showed normal epithelial differentiation over the polymer. The material in first white opaque became progressively transparent after colonization and demonstrated that an opaque hydrophobic material may become transparent and completely wettable with very low perturbation of the flow through the cornea.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherPubl by Int Soc for Optical Engineering
Pages108-114
Number of pages7
ISBN (Print)0819407909
StatePublished - Dec 1 1992
Externally publishedYes
EventOphthalmic Technologies II - Los Angeles, CA, USA
Duration: Jan 19 1992Jan 21 1992

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume1644
ISSN (Print)0277-786X

Other

OtherOphthalmic Technologies II
CityLos Angeles, CA, USA
Period1/19/921/21/92

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ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Legeais, J. M. M. D., Renard, G., Parel, J. M., Simon, G. M. D., & Pouliquen, Y. (1992). Artificial cornea: cellular ingrowth and transparency of an expanded polytetrafluoroethylene. In Proceedings of SPIE - The International Society for Optical Engineering (pp. 108-114). (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 1644). Publ by Int Soc for Optical Engineering.