Abstract
The development of a matrix with high cell adhesion and ingrowth rates is of importance for artificial cornea. The design of such artificial matrices requires understanding of cellular system colonization processes. After lamellar implementation the more impermeable the material, the larger the diameter and the more anterior placement, the more likely it is that the anterior stroma will starve and become necrotic. One approach to this problem is fenestration or open porosity of the material. Modifications in the thickness, pore size, and their geometric orientation of an expanded polytetrafluorethylene could modify the cellular ingrowth rate. Immunohistochemical study with the monoclonal antibodies AE5 showed normal epithelial differentiation over the polymer. The material in first white opaque became progressively transparent after colonization and demonstrated that an opaque hydrophobic material may become transparent and completely wettable with very low perturbation of the flow through the cornea.
| Original language | English |
|---|---|
| Title of host publication | Proceedings of SPIE - The International Society for Optical Engineering |
| Place of Publication | Bellingham, WA, United States |
| Publisher | Publ by Int Soc for Optical Engineering |
| Pages | 108-114 |
| Number of pages | 7 |
| Volume | 1644 |
| ISBN (Print) | 0819407909 |
| State | Published - Dec 1 1992 |
| Externally published | Yes |
| Event | Ophthalmic Technologies II - Los Angeles, CA, USA Duration: Jan 19 1992 → Jan 21 1992 |
Other
| Other | Ophthalmic Technologies II |
|---|---|
| City | Los Angeles, CA, USA |
| Period | 1/19/92 → 1/21/92 |
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ASJC Scopus subject areas
- Electrical and Electronic Engineering
- Condensed Matter Physics
Cite this
Artificial cornea : cellular ingrowth and transparency of an expanded polytetrafluoroethylene. / Legeais, Jean Marc M D; Renard, Gilles; Parel, Jean-Marie A; Simon, Gabriel M D; Pouliquen, Yves.
Proceedings of SPIE - The International Society for Optical Engineering. Vol. 1644 Bellingham, WA, United States : Publ by Int Soc for Optical Engineering, 1992. p. 108-114.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Artificial cornea
T2 - cellular ingrowth and transparency of an expanded polytetrafluoroethylene
AU - Legeais, Jean Marc M D
AU - Renard, Gilles
AU - Parel, Jean-Marie A
AU - Simon, Gabriel M D
AU - Pouliquen, Yves
PY - 1992/12/1
Y1 - 1992/12/1
N2 - The development of a matrix with high cell adhesion and ingrowth rates is of importance for artificial cornea. The design of such artificial matrices requires understanding of cellular system colonization processes. After lamellar implementation the more impermeable the material, the larger the diameter and the more anterior placement, the more likely it is that the anterior stroma will starve and become necrotic. One approach to this problem is fenestration or open porosity of the material. Modifications in the thickness, pore size, and their geometric orientation of an expanded polytetrafluorethylene could modify the cellular ingrowth rate. Immunohistochemical study with the monoclonal antibodies AE5 showed normal epithelial differentiation over the polymer. The material in first white opaque became progressively transparent after colonization and demonstrated that an opaque hydrophobic material may become transparent and completely wettable with very low perturbation of the flow through the cornea.
AB - The development of a matrix with high cell adhesion and ingrowth rates is of importance for artificial cornea. The design of such artificial matrices requires understanding of cellular system colonization processes. After lamellar implementation the more impermeable the material, the larger the diameter and the more anterior placement, the more likely it is that the anterior stroma will starve and become necrotic. One approach to this problem is fenestration or open porosity of the material. Modifications in the thickness, pore size, and their geometric orientation of an expanded polytetrafluorethylene could modify the cellular ingrowth rate. Immunohistochemical study with the monoclonal antibodies AE5 showed normal epithelial differentiation over the polymer. The material in first white opaque became progressively transparent after colonization and demonstrated that an opaque hydrophobic material may become transparent and completely wettable with very low perturbation of the flow through the cornea.
UR - http://www.scopus.com/inward/record.url?scp=0026965370&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026965370&partnerID=8YFLogxK
M3 - Conference contribution
SN - 0819407909
VL - 1644
SP - 108
EP - 114
BT - Proceedings of SPIE - The International Society for Optical Engineering
PB - Publ by Int Soc for Optical Engineering
CY - Bellingham, WA, United States
ER -