Artificial cornea

cellular ingrowth and transparency of an expanded polytetrafluoroethylene

Jean Marc M D Legeais, Gilles Renard, Jean-Marie A Parel, Gabriel M D Simon, Yves Pouliquen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

The development of a matrix with high cell adhesion and ingrowth rates is of importance for artificial cornea. The design of such artificial matrices requires understanding of cellular system colonization processes. After lamellar implementation the more impermeable the material, the larger the diameter and the more anterior placement, the more likely it is that the anterior stroma will starve and become necrotic. One approach to this problem is fenestration or open porosity of the material. Modifications in the thickness, pore size, and their geometric orientation of an expanded polytetrafluorethylene could modify the cellular ingrowth rate. Immunohistochemical study with the monoclonal antibodies AE5 showed normal epithelial differentiation over the polymer. The material in first white opaque became progressively transparent after colonization and demonstrated that an opaque hydrophobic material may become transparent and completely wettable with very low perturbation of the flow through the cornea.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Place of PublicationBellingham, WA, United States
PublisherPubl by Int Soc for Optical Engineering
Pages108-114
Number of pages7
Volume1644
ISBN (Print)0819407909
StatePublished - Dec 1 1992
Externally publishedYes
EventOphthalmic Technologies II - Los Angeles, CA, USA
Duration: Jan 19 1992Jan 21 1992

Other

OtherOphthalmic Technologies II
CityLos Angeles, CA, USA
Period1/19/921/21/92

Fingerprint

cornea
polytetrafluoroethylene
Polytetrafluoroethylenes
Transparency
porosity
matrices
antibodies
adhesion
perturbation
Monoclonal antibodies
Cell adhesion
polymers
cells
Pore size
Porosity
Polymers

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Legeais, J. M. M. D., Renard, G., Parel, J-M. A., Simon, G. M. D., & Pouliquen, Y. (1992). Artificial cornea: cellular ingrowth and transparency of an expanded polytetrafluoroethylene. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1644, pp. 108-114). Bellingham, WA, United States: Publ by Int Soc for Optical Engineering.

Artificial cornea : cellular ingrowth and transparency of an expanded polytetrafluoroethylene. / Legeais, Jean Marc M D; Renard, Gilles; Parel, Jean-Marie A; Simon, Gabriel M D; Pouliquen, Yves.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 1644 Bellingham, WA, United States : Publ by Int Soc for Optical Engineering, 1992. p. 108-114.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Legeais, JMMD, Renard, G, Parel, J-MA, Simon, GMD & Pouliquen, Y 1992, Artificial cornea: cellular ingrowth and transparency of an expanded polytetrafluoroethylene. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 1644, Publ by Int Soc for Optical Engineering, Bellingham, WA, United States, pp. 108-114, Ophthalmic Technologies II, Los Angeles, CA, USA, 1/19/92.
Legeais JMMD, Renard G, Parel J-MA, Simon GMD, Pouliquen Y. Artificial cornea: cellular ingrowth and transparency of an expanded polytetrafluoroethylene. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 1644. Bellingham, WA, United States: Publ by Int Soc for Optical Engineering. 1992. p. 108-114
Legeais, Jean Marc M D ; Renard, Gilles ; Parel, Jean-Marie A ; Simon, Gabriel M D ; Pouliquen, Yves. / Artificial cornea : cellular ingrowth and transparency of an expanded polytetrafluoroethylene. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 1644 Bellingham, WA, United States : Publ by Int Soc for Optical Engineering, 1992. pp. 108-114
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