Arterial homeostasis, inflammation, and erythropoietic growth factors

Pascal J. Goldschmidt-Clermont, Anna Mae Diehl

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

A neurohumoral link between kidneys and the heart has been established, particularly in the context of hypertension and cardiomyopathy. Beyond this neuro-endocrine pathway, another connecting system theoretically recruits growth factors that are selectively produced by the kidneys and have the ability to promote a distant reaction at the level of bone marrow. This reaction differentiates and circulates vascular progenitor cells capable of repairing the injured cardiovascular system. Reducing injuries (prevention) stabilizes disease processes by reducing tissue damage and destruction but the gradual degradation of the body's natural repair mechanisms eventually allows progressive reactivation of disease processes. In this light, a focus on tissue repair rather than injury prevention may hold the key to controlling chronic heart diseases. This article examines the medical therapies, including recombinant human erythropoietin, that have been shown to improve the function and survival of endothelial progenitor cells and promote the healing of damaged tissue.

Original languageEnglish (US)
Pages (from-to)S22-S26
JournalReviews in Cardiovascular Medicine
Volume6
Issue numberSUPPL. 3
StatePublished - Dec 14 2005

Keywords

  • Endothelial progenitor cells
  • Erythropoietin
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Goldschmidt-Clermont, P. J., & Diehl, A. M. (2005). Arterial homeostasis, inflammation, and erythropoietic growth factors. Reviews in Cardiovascular Medicine, 6(SUPPL. 3), S22-S26.