Arrhythmias in Chagasic Cardiomyopathy

Chris Healy, Juan Viles Gonzalez, Luis C. Sáenz, Mariana Soto, Juan D. Ramírez, Andre d'Avila

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Chagas disease, a chronic parasitosis caused by the protozoa Trypanosoma cruzi, is an increasing worldwide problem because of the number of cases in endemic areas and the migration of infected individuals to more developed regions. Chagas disease affects the heart through cardiac parasympathetic neuronal depopulation, immune-mediated myocardial injury, parasite persistence in cardiac tissue with secondary antigenic stimulation, and coronary microvascular abnormalities causing myocardial ischemia. A lack of knowledge exists for risk stratification, management, and prevention of ventricular arrhythmias in patients with chagasic cardiomyopathy. Catheter ablation can be effective for the management of recurrent ventricular tachycardia.

Original languageEnglish (US)
Pages (from-to)251-268
Number of pages18
JournalCardiac Electrophysiology Clinics
Volume7
Issue number2
DOIs
StatePublished - Jun 1 2015

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Keywords

  • Chagas disease
  • Epicardial ablation
  • Sudden cardiac death
  • Trypanosoma cruzi
  • Ventricular tachycardia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Healy, C., Viles Gonzalez, J., Sáenz, L. C., Soto, M., Ramírez, J. D., & d'Avila, A. (2015). Arrhythmias in Chagasic Cardiomyopathy. Cardiac Electrophysiology Clinics, 7(2), 251-268. https://doi.org/10.1016/j.ccep.2015.03.016