Array data extractor (ADE): A LabVIEW program to extract and merge gene array data

Stefan Kurtenbach, Sarah Kurtenbach, Georg Zoidl

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Large data sets from gene expression array studies are publicly available offering information highly valuable for research across many disciplines ranging from fundamental to clinical research. Highly advanced bioinformatics tools have been made available to researchers, but a demand for user-friendly software allowing researchers to quickly extract expression information for multiple genes from multiple studies persists. Findings. Here, we present a user-friendly LabVIEW program to automatically extract gene expression data for a list of genes from multiple normalized microarray datasets. Functionality was tested for 288 class A G protein-coupled receptors (GPCRs) and expression data from 12 studies comparing normal and diseased human hearts. Results confirmed known regulation of a beta 1 adrenergic receptor and further indicate novel research targets. Conclusions: Although existing software allows for complex data analyses, the LabVIEW based program presented here, "Array Data Extractor (ADE)", provides users with a tool to retrieve meaningful information from multiple normalized gene expression datasets in a fast and easy way. Further, the graphical programming language used in LabVIEW allows applying changes to the program without the need of advanced programming knowledge.

Original languageEnglish (US)
Article number496
JournalBMC Research Notes
Volume6
Issue number1
DOIs
StatePublished - Dec 1 2013
Externally publishedYes

Keywords

  • ADE
  • Array Data Extractor
  • Combining of multiple datasets
  • Gene expression array
  • Merge p-values
  • Meta-analysis
  • Microarray data analysis
  • Statistics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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