Aripiprazol - Führt ein neuer wirkungsmechanismus zu einer neuen qualität in der schizophrenie-therapie?

Translated title of the contribution: Aripiprazole - Can a new pharmacological mode of action lead to a new quality in the treatment of schizophrenia?

Michael Riedel, Martin Strassnig, Kai Uwe Kühn, Norbert Müller, Hans Jürgen Möller

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Aripiprazole is a new antipsychotic drug with a new mode of action in the treatment of schizophrenic psychoses. It acts via dopamine-D2 and serotonin-5-HT1A receptors as a partial agonist and shows blocking actions against 5-HT2A receptors. Its unique mode of action as a dopamine-serotonin stabilizer makes aripiprazole a welcome addition to presently available neuroleptics. The effectiveness and high tolerability of aripiprazole in the treatment of schizophrenic psychoses was proven in numerous preclinical and clinical studies. Experience to present has shown that negative symptoms can be positively influenced. It has also shown to be effective in the treatment of depressive symptoms that present in the course of schizophrenic psychoses. Extra-pyramidal side-effects were seen only slightly more often than under placebo conditions. Prolactin levels dropped on average.

Translated title of the contributionAripiprazole - Can a new pharmacological mode of action lead to a new quality in the treatment of schizophrenia?
Original languageGerman
Pages (from-to)46-54
Number of pages9
JournalPsychopharmakotherapie
Volume10
Issue number2
StatePublished - May 2003
Externally publishedYes

Keywords

  • Aripiprazole
  • Atypical neuroleptics
  • Effectiveness
  • Schizophrenia
  • Tolerability

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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