Are there clinical differences between familial and nonfamilial Alzheimer's disease?

Daniel J. Luchins, Donna Cohen, Patricia Hanrahan, Carl Eisdorfer, Gregory Paveza, J. Wesson Ashford, Philip Gorelick, Robert Hirschman, Sally Freels, Paul Levy, Todd Semla, Helen Shaw

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: The purpose of the study was to determine whether there are differences in clinical characteristics in two groups of patients with Alzheimer's disease, those reported to have a family history of dementia and those without a family history of dementia. Method: Using a data set from an Alzheimer's disease patient registry, funded as part of a National Institute on Aging cooperative agreement, the authors made comparisons of sociodemographic and clinical variables in a group of 462 patients with Alzheimer's disease, 172 reported to have at least one first-degree relative with dementia and 290 classified with no family history. Results: Patients with a presumptive family history differed from those without a family history in two ways: the course of dementia was described as having a fast rather than a slow progression from onset of symptoms to diagnosis, and caregivers reported a higher prevalence of family history of psychiatric disorders. There were no significant differences in age at onset, duration, female gender, aphasia and apraxia, handedness, family history of Down's syndrome, or number of children, brothers, and sisters. Conclusions: The association of faster course and family history of psychiatric disorders in the patients with a family history of dementia is consistent with the hypothesis of heterogeneity, but the overall results could also be explained by a genetic-environmental model of Alzheimer's disease.

Original languageEnglish
Pages (from-to)1023-1027
Number of pages5
JournalAmerican Journal of Psychiatry
Volume149
Issue number8
StatePublished - Dec 1 1992
Externally publishedYes

Fingerprint

Alzheimer Disease
Dementia
Psychiatry
Siblings
National Institute on Aging (U.S.)
Apraxias
Functional Laterality
Aphasia
Genetic Models
Down Syndrome
Age of Onset
Caregivers
Registries

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Luchins, D. J., Cohen, D., Hanrahan, P., Eisdorfer, C., Paveza, G., Wesson Ashford, J., ... Shaw, H. (1992). Are there clinical differences between familial and nonfamilial Alzheimer's disease? American Journal of Psychiatry, 149(8), 1023-1027.

Are there clinical differences between familial and nonfamilial Alzheimer's disease? / Luchins, Daniel J.; Cohen, Donna; Hanrahan, Patricia; Eisdorfer, Carl; Paveza, Gregory; Wesson Ashford, J.; Gorelick, Philip; Hirschman, Robert; Freels, Sally; Levy, Paul; Semla, Todd; Shaw, Helen.

In: American Journal of Psychiatry, Vol. 149, No. 8, 01.12.1992, p. 1023-1027.

Research output: Contribution to journalArticle

Luchins, DJ, Cohen, D, Hanrahan, P, Eisdorfer, C, Paveza, G, Wesson Ashford, J, Gorelick, P, Hirschman, R, Freels, S, Levy, P, Semla, T & Shaw, H 1992, 'Are there clinical differences between familial and nonfamilial Alzheimer's disease?', American Journal of Psychiatry, vol. 149, no. 8, pp. 1023-1027.
Luchins DJ, Cohen D, Hanrahan P, Eisdorfer C, Paveza G, Wesson Ashford J et al. Are there clinical differences between familial and nonfamilial Alzheimer's disease? American Journal of Psychiatry. 1992 Dec 1;149(8):1023-1027.
Luchins, Daniel J. ; Cohen, Donna ; Hanrahan, Patricia ; Eisdorfer, Carl ; Paveza, Gregory ; Wesson Ashford, J. ; Gorelick, Philip ; Hirschman, Robert ; Freels, Sally ; Levy, Paul ; Semla, Todd ; Shaw, Helen. / Are there clinical differences between familial and nonfamilial Alzheimer's disease?. In: American Journal of Psychiatry. 1992 ; Vol. 149, No. 8. pp. 1023-1027.
@article{1cef41e906244db2b024d9fd338a260d,
title = "Are there clinical differences between familial and nonfamilial Alzheimer's disease?",
abstract = "Objective: The purpose of the study was to determine whether there are differences in clinical characteristics in two groups of patients with Alzheimer's disease, those reported to have a family history of dementia and those without a family history of dementia. Method: Using a data set from an Alzheimer's disease patient registry, funded as part of a National Institute on Aging cooperative agreement, the authors made comparisons of sociodemographic and clinical variables in a group of 462 patients with Alzheimer's disease, 172 reported to have at least one first-degree relative with dementia and 290 classified with no family history. Results: Patients with a presumptive family history differed from those without a family history in two ways: the course of dementia was described as having a fast rather than a slow progression from onset of symptoms to diagnosis, and caregivers reported a higher prevalence of family history of psychiatric disorders. There were no significant differences in age at onset, duration, female gender, aphasia and apraxia, handedness, family history of Down's syndrome, or number of children, brothers, and sisters. Conclusions: The association of faster course and family history of psychiatric disorders in the patients with a family history of dementia is consistent with the hypothesis of heterogeneity, but the overall results could also be explained by a genetic-environmental model of Alzheimer's disease.",
author = "Luchins, {Daniel J.} and Donna Cohen and Patricia Hanrahan and Carl Eisdorfer and Gregory Paveza and {Wesson Ashford}, J. and Philip Gorelick and Robert Hirschman and Sally Freels and Paul Levy and Todd Semla and Helen Shaw",
year = "1992",
month = "12",
day = "1",
language = "English",
volume = "149",
pages = "1023--1027",
journal = "American Journal of Psychiatry",
issn = "0002-953X",
publisher = "American Psychiatric Association",
number = "8",

}

TY - JOUR

T1 - Are there clinical differences between familial and nonfamilial Alzheimer's disease?

AU - Luchins, Daniel J.

AU - Cohen, Donna

AU - Hanrahan, Patricia

AU - Eisdorfer, Carl

AU - Paveza, Gregory

AU - Wesson Ashford, J.

AU - Gorelick, Philip

AU - Hirschman, Robert

AU - Freels, Sally

AU - Levy, Paul

AU - Semla, Todd

AU - Shaw, Helen

PY - 1992/12/1

Y1 - 1992/12/1

N2 - Objective: The purpose of the study was to determine whether there are differences in clinical characteristics in two groups of patients with Alzheimer's disease, those reported to have a family history of dementia and those without a family history of dementia. Method: Using a data set from an Alzheimer's disease patient registry, funded as part of a National Institute on Aging cooperative agreement, the authors made comparisons of sociodemographic and clinical variables in a group of 462 patients with Alzheimer's disease, 172 reported to have at least one first-degree relative with dementia and 290 classified with no family history. Results: Patients with a presumptive family history differed from those without a family history in two ways: the course of dementia was described as having a fast rather than a slow progression from onset of symptoms to diagnosis, and caregivers reported a higher prevalence of family history of psychiatric disorders. There were no significant differences in age at onset, duration, female gender, aphasia and apraxia, handedness, family history of Down's syndrome, or number of children, brothers, and sisters. Conclusions: The association of faster course and family history of psychiatric disorders in the patients with a family history of dementia is consistent with the hypothesis of heterogeneity, but the overall results could also be explained by a genetic-environmental model of Alzheimer's disease.

AB - Objective: The purpose of the study was to determine whether there are differences in clinical characteristics in two groups of patients with Alzheimer's disease, those reported to have a family history of dementia and those without a family history of dementia. Method: Using a data set from an Alzheimer's disease patient registry, funded as part of a National Institute on Aging cooperative agreement, the authors made comparisons of sociodemographic and clinical variables in a group of 462 patients with Alzheimer's disease, 172 reported to have at least one first-degree relative with dementia and 290 classified with no family history. Results: Patients with a presumptive family history differed from those without a family history in two ways: the course of dementia was described as having a fast rather than a slow progression from onset of symptoms to diagnosis, and caregivers reported a higher prevalence of family history of psychiatric disorders. There were no significant differences in age at onset, duration, female gender, aphasia and apraxia, handedness, family history of Down's syndrome, or number of children, brothers, and sisters. Conclusions: The association of faster course and family history of psychiatric disorders in the patients with a family history of dementia is consistent with the hypothesis of heterogeneity, but the overall results could also be explained by a genetic-environmental model of Alzheimer's disease.

UR - http://www.scopus.com/inward/record.url?scp=0026722092&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026722092&partnerID=8YFLogxK

M3 - Article

VL - 149

SP - 1023

EP - 1027

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

SN - 0002-953X

IS - 8

ER -