Are the spatio-temporal firings of pyramidal cells and interneurons markers of impending seizures?

Jeremiah D. Mitzelfelt, Justin C. Sanchez

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Current pharmacological, electrophysiological, and surgical treatments are not always effective for all epileptic syndromes. In analyzing the clinical utility, traditional EEG analysis provides a coarse representation of the neuronal activity and we hypothesize that for chronic, in vivo epilepsy research more specific electrophysiological techniques are necessary. In order to increase our understanding of single unit behavior in an epileptic network, this study recorded preseizure single unit firing rates from pyramidal cells and interneurons in an epileptic rat model of temporal lobe epilepsy. The information gained from this study seeks to aid in the development of new seizure warning and control methods.

Original languageEnglish (US)
Title of host publicationProceedings of the 3rd International IEEE EMBS Conference on Neural Engineering
Pages265-268
Number of pages4
DOIs
StatePublished - Sep 25 2007
Event3rd International IEEE EMBS Conference on Neural Engineering - Kohala Coast, HI, United States
Duration: May 2 2007May 5 2007

Publication series

NameProceedings of the 3rd International IEEE EMBS Conference on Neural Engineering

Other

Other3rd International IEEE EMBS Conference on Neural Engineering
CountryUnited States
CityKohala Coast, HI
Period5/2/075/5/07

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Neuroscience (miscellaneous)

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  • Cite this

    Mitzelfelt, J. D., & Sanchez, J. C. (2007). Are the spatio-temporal firings of pyramidal cells and interneurons markers of impending seizures? In Proceedings of the 3rd International IEEE EMBS Conference on Neural Engineering (pp. 265-268). [4227267] (Proceedings of the 3rd International IEEE EMBS Conference on Neural Engineering). https://doi.org/10.1109/CNE.2007.369662