Are the spatio-temporal firings of pyramidal cells and interneurons markers of impending seizures?

Jeremiah D. Mitzelfelt; Justin C. Sanchez

doi:10.1109/CNE.2007.369662

Are the spatio-temporal firings of pyramidal cells and interneurons markers of impending seizures?

Jeremiah D. Mitzelfelt, Justin C. Sanchez

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Current pharmacological, electrophysiological, and surgical treatments are not always effective for all epileptic syndromes. In analyzing the clinical utility, traditional EEG analysis provides a coarse representation of the neuronal activity and we hypothesize that for chronic, in vivo epilepsy research more specific electrophysiological techniques are necessary. In order to increase our understanding of single unit behavior in an epileptic network, this study recorded preseizure single unit firing rates from pyramidal cells and interneurons in an epileptic rat model of temporal lobe epilepsy. The information gained from this study seeks to aid in the development of new seizure warning and control methods.

Original language	English (US)
Title of host publication	Proceedings of the 3rd International IEEE EMBS Conference on Neural Engineering
Pages	265-268
Number of pages	4
DOIs	https://doi.org/10.1109/CNE.2007.369662
State	Published - Sep 25 2007
Event	3rd International IEEE EMBS Conference on Neural Engineering - Kohala Coast, HI, United States Duration: May 2 2007 → May 5 2007

Publication series

Name	Proceedings of the 3rd International IEEE EMBS Conference on Neural Engineering

Other

Other	3rd International IEEE EMBS Conference on Neural Engineering
Country/Territory	United States
City	Kohala Coast, HI
Period	5/2/07 → 5/5/07

ASJC Scopus subject areas

Biotechnology
Bioengineering
Neuroscience (miscellaneous)

Access to Document

10.1109/CNE.2007.369662

Cite this

Mitzelfelt, J. D., & Sanchez, J. C. (2007). Are the spatio-temporal firings of pyramidal cells and interneurons markers of impending seizures? In Proceedings of the 3rd International IEEE EMBS Conference on Neural Engineering (pp. 265-268). [4227267] (Proceedings of the 3rd International IEEE EMBS Conference on Neural Engineering). https://doi.org/10.1109/CNE.2007.369662

Are the spatio-temporal firings of pyramidal cells and interneurons markers of impending seizures? / Mitzelfelt, Jeremiah D.; Sanchez, Justin C.

Proceedings of the 3rd International IEEE EMBS Conference on Neural Engineering. 2007. p. 265-268 4227267 (Proceedings of the 3rd International IEEE EMBS Conference on Neural Engineering).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Mitzelfelt, JD & Sanchez, JC 2007, Are the spatio-temporal firings of pyramidal cells and interneurons markers of impending seizures? in Proceedings of the 3rd International IEEE EMBS Conference on Neural Engineering., 4227267, Proceedings of the 3rd International IEEE EMBS Conference on Neural Engineering, pp. 265-268, 3rd International IEEE EMBS Conference on Neural Engineering, Kohala Coast, HI, United States, 5/2/07. https://doi.org/10.1109/CNE.2007.369662

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title = "Are the spatio-temporal firings of pyramidal cells and interneurons markers of impending seizures?",

abstract = "Current pharmacological, electrophysiological, and surgical treatments are not always effective for all epileptic syndromes. In analyzing the clinical utility, traditional EEG analysis provides a coarse representation of the neuronal activity and we hypothesize that for chronic, in vivo epilepsy research more specific electrophysiological techniques are necessary. In order to increase our understanding of single unit behavior in an epileptic network, this study recorded preseizure single unit firing rates from pyramidal cells and interneurons in an epileptic rat model of temporal lobe epilepsy. The information gained from this study seeks to aid in the development of new seizure warning and control methods.",

author = "Mitzelfelt, {Jeremiah D.} and Sanchez, {Justin C.}",

year = "2007",

month = sep,

day = "25",

doi = "10.1109/CNE.2007.369662",

language = "English (US)",

isbn = "1424407923",

series = "Proceedings of the 3rd International IEEE EMBS Conference on Neural Engineering",

pages = "265--268",

booktitle = "Proceedings of the 3rd International IEEE EMBS Conference on Neural Engineering",

note = "3rd International IEEE EMBS Conference on Neural Engineering ; Conference date: 02-05-2007 Through 05-05-2007",