Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium?

T. Tsuda, Roberto Lopez Alberola, E. A. Rogaeva, M. Freedman, E. Rogaev, D. Drachman, D. Pollen, J. Haines, Y. Liang, D. R. Crapper McLachlan, R. Duara, P. St George-Hyslop

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Abstract

Allele frequencies for polymorphisms in the apolipoprotein E and the apolipoprotein CII genes were determined in subjects of Ashkenazi Jewish origin with late-onset Alzheimer's disease and in unaffected control subjects from the same ethnic group. A significant association was observed between late-onset Alzheimer's disease and the ε4 (112(Cys→Arg)) allele of apolipoprotein E; however, no association was detected with apolipoprotein CII. These results suggest that the association with ε4 is probably not due to linkage disequilibrium.

Original languageEnglish
Pages (from-to)97-100
Number of pages4
JournalAnnals of Neurology
Volume36
Issue number1
DOIs
StatePublished - Jul 1 1994

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Apolipoprotein C-II
Linkage Disequilibrium
Apolipoproteins E
Alzheimer Disease
Ethnic Groups
Gene Frequency
Genes
Alleles

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium? / Tsuda, T.; Lopez Alberola, Roberto; Rogaeva, E. A.; Freedman, M.; Rogaev, E.; Drachman, D.; Pollen, D.; Haines, J.; Liang, Y.; Crapper McLachlan, D. R.; Duara, R.; St George-Hyslop, P.

In: Annals of Neurology, Vol. 36, No. 1, 01.07.1994, p. 97-100.

Research output: Contribution to journalArticle

Tsuda, T, Lopez Alberola, R, Rogaeva, EA, Freedman, M, Rogaev, E, Drachman, D, Pollen, D, Haines, J, Liang, Y, Crapper McLachlan, DR, Duara, R & St George-Hyslop, P 1994, 'Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium?', Annals of Neurology, vol. 36, no. 1, pp. 97-100. https://doi.org/10.1002/ana.410360118
Tsuda, T. ; Lopez Alberola, Roberto ; Rogaeva, E. A. ; Freedman, M. ; Rogaev, E. ; Drachman, D. ; Pollen, D. ; Haines, J. ; Liang, Y. ; Crapper McLachlan, D. R. ; Duara, R. ; St George-Hyslop, P. / Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium?. In: Annals of Neurology. 1994 ; Vol. 36, No. 1. pp. 97-100.
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