Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium?

T. Tsuda, R. Lopez, E. A. Rogaeva, M. Freedman, E. Rogaev, D. Drachman, D. Pollen, J. Haines, Y. Liang, D. R.Crapper McLachlan, R. Duara, P. St George‐Hyslop

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41 Scopus citations

Abstract

Allele frequencies for polymorphisms in the apolipoprotein E and the apolipoprotein CII genes were determined in subjects of Ashkenazi Jewish origin with late-onset Alzheimer's disease and in unaffected control subjects from the same ethnic group. A significant association was observed between late-onset Alzheimer's disease and the ε4 (112(Cys→Arg)) allele of apolipoprotein E; however, no association was detected with apolipoprotein CII. These results suggest that the association with ε4 is probably not due to linkage disequilibrium.

Original languageEnglish (US)
Pages (from-to)97-100
Number of pages4
JournalAnnals of neurology
Volume36
Issue number1
DOIs
StatePublished - Jul 1994

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Tsuda, T., Lopez, R., Rogaeva, E. A., Freedman, M., Rogaev, E., Drachman, D., Pollen, D., Haines, J., Liang, Y., McLachlan, D. R. C., Duara, R., & St George‐Hyslop, P. (1994). Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium? Annals of neurology, 36(1), 97-100. https://doi.org/10.1002/ana.410360118