Are platelets the link between depression and ischemic heart disease?

Charles Nemeroff, Dominique Musselman

Research output: Contribution to journal › Article

177 Citations (Scopus)

Abstract

The role of platelets as the link between ischemic heart disease and depression is reviewed. Platelet function abnormalities, including increased platelet reactivity, may predispose depressed patients to dotting diatheses and may explain their vulnerability to cardiovascular disease. Platelet physiologic characteristics, influences on platelet response, and indicators of platelet reactivity are discussed. Measurements of platelet activation, secretion, and aggregation have enabled the study of platelet responses in patients with major depression. The findings of clinical trials evaluating platelet responses to antidepressant treatment are described, and recommendations for future studies are proposed.

Original languageEnglish
JournalAmerican Heart Journal
Volume140
Issue number4 SUPPL.
StatePublished - Oct 23 2000
Externally publishedYes

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Myocardial Ischemia
Blood Platelets
Disease Susceptibility
Platelet Activation
Platelet Aggregation
Antidepressive Agents
Cardiovascular Diseases
Clinical Trials

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Are platelets the link between depression and ischemic heart disease? / Nemeroff, Charles; Musselman, Dominique.

In: American Heart Journal, Vol. 140, No. 4 SUPPL., 23.10.2000.

Research output: Contribution to journal › Article

Nemeroff, C & Musselman, D 2000, 'Are platelets the link between depression and ischemic heart disease?', American Heart Journal, vol. 140, no. 4 SUPPL..
Nemeroff C, Musselman D. Are platelets the link between depression and ischemic heart disease? American Heart Journal. 2000 Oct 23;140(4 SUPPL.).
Nemeroff, Charles ; Musselman, Dominique. / Are platelets the link between depression and ischemic heart disease?. In: American Heart Journal. 2000 ; Vol. 140, No. 4 SUPPL.
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