TY - JOUR
T1 - Are platelets the link between depression and ischemic heart disease?
AU - Nemeroff, Charles B.
AU - Musselman, Dominique L.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2000
Y1 - 2000
N2 - The role of platelets as the link between ischemic heart disease and depression is reviewed. Platelet function abnormalities, including increased platelet reactivity, may predispose depressed patients to dotting diatheses and may explain their vulnerability to cardiovascular disease. Platelet physiologic characteristics, influences on platelet response, and indicators of platelet reactivity are discussed. Measurements of platelet activation, secretion, and aggregation have enabled the study of platelet responses in patients with major depression. The findings of clinical trials evaluating platelet responses to antidepressant treatment are described, and recommendations for future studies are proposed.
AB - The role of platelets as the link between ischemic heart disease and depression is reviewed. Platelet function abnormalities, including increased platelet reactivity, may predispose depressed patients to dotting diatheses and may explain their vulnerability to cardiovascular disease. Platelet physiologic characteristics, influences on platelet response, and indicators of platelet reactivity are discussed. Measurements of platelet activation, secretion, and aggregation have enabled the study of platelet responses in patients with major depression. The findings of clinical trials evaluating platelet responses to antidepressant treatment are described, and recommendations for future studies are proposed.
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U2 - 10.1067/mhj.2000.109978
DO - 10.1067/mhj.2000.109978
M3 - Article
C2 - 11011349
AN - SCOPUS:0033780293
VL - 140
SP - S57-S62
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 4 SUPPL.
ER -