Are L-tyrosine and L-dopa hormone-like bioregulators?

Andrzej Slominski, Ralf Paus

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Some amino acids have bioregulatory functions, which far exceed those of precursors for proteins or of substrates for specific enzymes. Two of these amino acids, L-tyrosine and L-dopa, are precursors to melanin and catecholamines. In vertebrates, they can act as inducers and regulators of the melanogenic apparatus and of MSH receptors-two quite complex functions that could hardly be performed by mere substrates. Focussing on the pigmentary system as a study model, we therefore explore the hypothesis that L-tyrosine and L-dopa act as hormone-like bioregulators in mammals, with melanocytes regulating tyrosine and dopa activity via their metabolic consumption.

Original languageEnglish (US)
Pages (from-to)123-138
Number of pages16
JournalJournal of theoretical biology
Volume143
Issue number1
DOIs
StatePublished - Mar 8 1990
Externally publishedYes

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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