Are L-tyrosine and L-dopa hormone-like bioregulators?

Andrzej Slominski, Ralf Paus

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Some amino acids have bioregulatory functions, which far exceed those of precursors for proteins or of substrates for specific enzymes. Two of these amino acids, L-tyrosine and L-dopa, are precursors to melanin and catecholamines. In vertebrates, they can act as inducers and regulators of the melanogenic apparatus and of MSH receptors-two quite complex functions that could hardly be performed by mere substrates. Focussing on the pigmentary system as a study model, we therefore explore the hypothesis that L-tyrosine and L-dopa act as hormone-like bioregulators in mammals, with melanocytes regulating tyrosine and dopa activity via their metabolic consumption.

Original languageEnglish (US)
Pages (from-to)123-138
Number of pages16
JournalJournal of theoretical biology
Volume143
Issue number1
DOIs
StatePublished - Mar 8 1990
Externally publishedYes

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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