Arachidonic acid metabolites: Basic concepts relevant to plastic surgery

K. G. Proctor, S. Shatkin

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

AA is the precursor of oxygenated metabolites called the eicosanoids, that are generated by the cyclooxygenase, lipoxygenase, or cytochrome P450 enzymatic pathways. The biologically active eicosanoids are labile, usually but not always, act near their site of synthesis, and are not stored in any tissue to any appreciable degree. In most tissues, there is a continuous low-level synthesis that is probably essential to normal function. Injury or surgical trauma can evoke a dramatic change in the quality and quantitiy of the metabolites. Pharmacologic manipulation of the pathways of AA metabolism, or alteration of the effects of AA metabolites, can significantly improve tissue perfusion in a variety of clinical situations.

Original languageEnglish (US)
Pages (from-to)421-426
Number of pages6
JournalJournal of Reconstructive Microsurgery
Volume4
Issue number5
DOIs
StatePublished - Jan 1 1988

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ASJC Scopus subject areas

  • Surgery

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