Arachidonic acid metabolites: Basic concepts relevant to plastic surgery

Kenneth G Proctor, S. Shatkin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

AA is the precursor of oxygenated metabolites called the eicosanoids, that are generated by the cyclooxygenase, lipoxygenase, or cytochrome P450 enzymatic pathways. The biologically active eicosanoids are labile, usually but not always, act near their site of synthesis, and are not stored in any tissue to any appreciable degree. In most tissues, there is a continuous low-level synthesis that is probably essential to normal function. Injury or surgical trauma can evoke a dramatic change in the quality and quantitiy of the metabolites. Pharmacologic manipulation of the pathways of AA metabolism, or alteration of the effects of AA metabolites, can significantly improve tissue perfusion in a variety of clinical situations.

Original languageEnglish
Pages (from-to)421-426
Number of pages6
JournalJournal of Reconstructive Microsurgery
Volume4
Issue number5
StatePublished - Jan 1 1988
Externally publishedYes

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Plastic Surgery
Arachidonic Acid
Eicosanoids
Lipoxygenase
Intraoperative Complications
Prostaglandin-Endoperoxide Synthases
Cytochrome P-450 Enzyme System
Perfusion
Wounds and Injuries

ASJC Scopus subject areas

  • Surgery

Cite this

Arachidonic acid metabolites : Basic concepts relevant to plastic surgery. / Proctor, Kenneth G; Shatkin, S.

In: Journal of Reconstructive Microsurgery, Vol. 4, No. 5, 01.01.1988, p. 421-426.

Research output: Contribution to journalArticle

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