Arachidonate lipoxygenase metabolites in amniotic fluid of women with intra-amniotic infection and preterm labor

R. Romero, R. Quintero, M. Emamian, M. Wan, C. Grzyboski, J. C. Hobbins, M. D. Mitchell

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

This study was undertaken to examine the effects of intrauterine infection and preterm labor on the amniotic fluid concentrations of arachidonate lipoxygenase metabolites in women with premature rupture of membranes. Amniotic fluid was obtained from four groups of women with premature rupture of membranes: group 1, women without labor or infection; group 2, women with labor but without infection; group 3, women with intra-amniotic infection but without labor; and group 4, women with both infection and labor. 12-Hydroxyeicosatetraenoic acid, 15-hydroxyeicosatetraenoic acid, and leukotriene B4 were measured by radioimmunoassays. Amniotic fluid concentrations of 12-hydroxyeicosatetraenoic acid were found not to differ significantly among the four groups. Amniotic fluid concentrations of 15-hydroxyeicosatetraenoic acid in group 4 were significantly higher than in women in groups 1 and 3 (p < 0.05). In addition, amniotic fluid concentrations in leukotriene B4 were significantly higher in group 4 than in any of the other three groups (p < 0.05). Leukotriene B4 concentrations were higher in groups 2 and 3 than in group 1, suggesting that the presence of both labor and infection increases the concentration of this metabolite in amniotic fluid. Infection and labor had an additive effect in the elevation of amniotic fluid concentrations of leukotriene B4. These results suggest that the amniotic fluid concentrations of arachidonate lipoxygenase metabolites are effected differently by the presence of infection and labor in women with premature rupture of membranes.

Original languageEnglish
Pages (from-to)1454-1460
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume157
Issue number6
StatePublished - Dec 1 1987

Fingerprint

Arachidonate Lipoxygenases
Premature Obstetric Labor
Amniotic Fluid
Hydroxyeicosatetraenoic Acids
Leukotriene B4
Infection
Rupture
Membranes
Radioimmunoassay

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Romero, R., Quintero, R., Emamian, M., Wan, M., Grzyboski, C., Hobbins, J. C., & Mitchell, M. D. (1987). Arachidonate lipoxygenase metabolites in amniotic fluid of women with intra-amniotic infection and preterm labor. American Journal of Obstetrics and Gynecology, 157(6), 1454-1460.

Arachidonate lipoxygenase metabolites in amniotic fluid of women with intra-amniotic infection and preterm labor. / Romero, R.; Quintero, R.; Emamian, M.; Wan, M.; Grzyboski, C.; Hobbins, J. C.; Mitchell, M. D.

In: American Journal of Obstetrics and Gynecology, Vol. 157, No. 6, 01.12.1987, p. 1454-1460.

Research output: Contribution to journalArticle

Romero, R, Quintero, R, Emamian, M, Wan, M, Grzyboski, C, Hobbins, JC & Mitchell, MD 1987, 'Arachidonate lipoxygenase metabolites in amniotic fluid of women with intra-amniotic infection and preterm labor', American Journal of Obstetrics and Gynecology, vol. 157, no. 6, pp. 1454-1460.
Romero, R. ; Quintero, R. ; Emamian, M. ; Wan, M. ; Grzyboski, C. ; Hobbins, J. C. ; Mitchell, M. D. / Arachidonate lipoxygenase metabolites in amniotic fluid of women with intra-amniotic infection and preterm labor. In: American Journal of Obstetrics and Gynecology. 1987 ; Vol. 157, No. 6. pp. 1454-1460.
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