Applications of helical-chiral pyridines as organocatalysts in asymmetric synthesis

Zhili Peng, Norito Takenaka

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

A new family of chiral pyridines has been designed and synthesized for use in asymmetric organocatalysis. Thus, helical-chiral pyridines induce high enantioselectivity in a range of mechanistically unrelated, synthetically significant transformations, including Friedel-Crafts alkylation with nitroalkenes, periselective Diels-Alder reactions with nitroalkenes, the ring-opening of epoxides with a chloride nucleophile, and the propargylation of aldehydes.

Original languageEnglish (US)
Pages (from-to)28-42
Number of pages15
JournalChemical Record
Volume13
Issue number1
DOIs
StatePublished - Feb 2013

Keywords

  • asymmetric catalysis
  • enantioselectivity
  • helical structures
  • organocatalysis
  • pyridines

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Chemical Engineering(all)
  • Materials Chemistry

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