Application of volumetric MR spectroscopic imaging for localization of neocortical epilepsy

Andrew A Maudsley, Claudia Domenig, R. Eugene Ramsay, Brian C. Bowen

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Purpose: The aim of this study was to evaluate volumetric proton magnetic resonance spectroscopic imaging (MRSI) for localization of epileptogenic foci in neocortical epilepsy. Methods: Twenty-five subjects reporting seizures considered to be of neocortical origin were recruited to take part in a 3-T MR study that included high-resolution structural MRI and a whole-brain MRSI acquisition. Using a fully automated MRSI processing protocol, maps for signal intensity normalized N-acetylaspartate (NAA), creatine, and choline were created, together with the relative volume fraction of grey-matter, white-matter, and CSF within each MRSI voxel. Analyses were performed using visual observation of the metabolite and metabolite ratio maps; voxel-based calculation of differences in these metabolite maps relative to normal controls; comparison of average grey-matter and white-matter metabolite values over each lobar volume; and examination of relative left-right asymmetry factors by brain region. Results: Data from 14 subjects were suitable for inclusion in the analysis. Eight subjects had MRI-visible pathologies that were associated with decreases in NAA/creatine, which extended beyond the volume indicated by the MRI. Five subjects demonstrated no significant metabolic alterations using any of the analysis methods, and one subject had no findings on MRI or MRSI. Conclusions: This proof of principle study supports previous evidence that alterations of MR-detected brain metabolites can be detected in tissue areas affected by neocortical seizure activity, while additionally demonstrating advantages of the volumetric MRSI approach.

Original languageEnglish
Pages (from-to)127-138
Number of pages12
JournalEpilepsy Research
Volume88
Issue number2-3
DOIs
StatePublished - Feb 1 2010

Fingerprint

Epilepsy
Magnetic Resonance Imaging
Creatine
Brain
Seizures
Choline
Protons
Observation
Pathology
N-acetylaspartate
White Matter
Gray Matter

Keywords

  • MR spectroscopy
  • MRI
  • MRSI
  • Neocortical epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Application of volumetric MR spectroscopic imaging for localization of neocortical epilepsy. / Maudsley, Andrew A; Domenig, Claudia; Ramsay, R. Eugene; Bowen, Brian C.

In: Epilepsy Research, Vol. 88, No. 2-3, 01.02.2010, p. 127-138.

Research output: Contribution to journalArticle

Maudsley, Andrew A ; Domenig, Claudia ; Ramsay, R. Eugene ; Bowen, Brian C. / Application of volumetric MR spectroscopic imaging for localization of neocortical epilepsy. In: Epilepsy Research. 2010 ; Vol. 88, No. 2-3. pp. 127-138.
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