Application of thermospray liquid chromatography-mass spectrometry for the analysis of chloramphenicol and three related compounds

W. A. Korfmacher, T. A. Getek, E. B. Hansen, C. E. Cerniglia, S. Abou-Khalil, Adel A Yunis

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Abstract

The thermospray (TS) liquid chromatographic-mass spectrometric analysis of the antibiotic chloramphenicol and three related compounds is presented. The three additional compounds are dehydrochloramphenicol, aminodehydrochloramphenicol, and nitrophenylaminopropanediol. Baseline separation of the four compounds is achieved. The TS mass spectrum of each of the four compounds includes a prominent [MH]+ ion plus some fragment ion peaks.

Original languageEnglish (US)
Pages (from-to)236-238
Number of pages3
JournalJournal of Chromatographic Science
Volume28
Issue number5
StatePublished - 1990
Externally publishedYes

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ASJC Scopus subject areas

  • Clinical Biochemistry
  • Analytical Chemistry

Cite this

Korfmacher, W. A., Getek, T. A., Hansen, E. B., Cerniglia, C. E., Abou-Khalil, S., & Yunis, A. A. (1990). Application of thermospray liquid chromatography-mass spectrometry for the analysis of chloramphenicol and three related compounds. Journal of Chromatographic Science, 28(5), 236-238.