Neuropathic pain is a debilitating chronic pain condition resulting in a marked decrease in the quality of life and secondary symptoms such as anxiety and depression. Existing therapies for neuropathic pain are far from effective for the majority of patients. Gene transfer using viral vectors provides the possibility of a highly selective targeted release of bioactive molecules within the nervous system for relief of neuropathic pain. This chapter addresses the preclinical studies with nonreplicating herpes simplex virus (HSV)-based vectors to transduce neurons in animal models of neuropathic pain.
|Original language||English (US)|
|Title of host publication||Gene Therapy in Neurological Disorders|
|Number of pages||12|
|State||Published - Jan 1 2018|
- Antiinflammatory cytokines
- Neuropathic pain
ASJC Scopus subject areas