Application of herpes simplex virus vectors in treatment of neuropathic pain

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Neuropathic pain is a debilitating chronic pain condition resulting in a marked decrease in the quality of life and secondary symptoms such as anxiety and depression. Existing therapies for neuropathic pain are far from effective for the majority of patients. Gene transfer using viral vectors provides the possibility of a highly selective targeted release of bioactive molecules within the nervous system for relief of neuropathic pain. This chapter addresses the preclinical studies with nonreplicating herpes simplex virus (HSV)-based vectors to transduce neurons in animal models of neuropathic pain.

Original languageEnglish (US)
Title of host publicationGene Therapy in Neurological Disorders
PublisherElsevier
Pages345-356
Number of pages12
ISBN (Electronic)9780128098134
ISBN (Print)9780128098219
DOIs
StatePublished - Jan 1 2018

Keywords

  • Antiinflammatory cytokines
  • Enkephalin
  • GAD67
  • HSV
  • Neuropathic pain

ASJC Scopus subject areas

  • Medicine(all)

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