Application of an Asthma Screening Questionnaire in Children with Sickle Cell Disease

Aravind Yadav, Fernando Corrales-Medina, James M. Stark, S. Shahrukh Hashmi, Mary P. Carroll, Keely G. Smith, Kristen M. Meulmester, Deborah L. Brown, Cindy Jon, Ricardo A. Mosquera

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: Asthma in sickle cell disease (SCD) patients is associated with elevated morbidity and mortality. Early detection and initiation of treatment may therefore lead to improved outcome. Utility of an asthma screening questionnaire to identify obstructive airway disease and physician diagnosed asthma in children with SCD at an outpatient setting as an effective, easy-to-administer screening tool has not previously been evaluated in this population. Methods: A previously validated asthma screening questionnaire and spirometry were prospectively administered to 41 SCD children at a routine clinic visit. Results: Prevalence of obstructive airway was 51.2% (n=21) and physician diagnosis of asthma 33.3% (n=13). Sensitivity (40%) and specificity (75%) of the questionnaire was poor in detecting obstructive airway disease, but sensitivity (77%), specificity (100%), positive predictive value (100%), and negative predictive value (90%) were high in detecting physician diagnosis of asthma. Conclusion: An asthma screening questionnaire could be a useful tool in identifying at-risk SCD children who may benefit from further management.

Original languageEnglish (US)
Pages (from-to)177-182
Number of pages6
JournalPediatric, Allergy, Immunology, and Pulmonology
Volume28
Issue number3
DOIs
StatePublished - Sep 1 2015

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Sickle Cell Anemia
Asthma
Physicians
Sensitivity and Specificity
Spirometry
Ambulatory Care
Surveys and Questionnaires
Outpatients
Morbidity
Mortality
Population

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Application of an Asthma Screening Questionnaire in Children with Sickle Cell Disease. / Yadav, Aravind; Corrales-Medina, Fernando; Stark, James M.; Hashmi, S. Shahrukh; Carroll, Mary P.; Smith, Keely G.; Meulmester, Kristen M.; Brown, Deborah L.; Jon, Cindy; Mosquera, Ricardo A.

In: Pediatric, Allergy, Immunology, and Pulmonology, Vol. 28, No. 3, 01.09.2015, p. 177-182.

Research output: Contribution to journalArticle

Yadav, A, Corrales-Medina, F, Stark, JM, Hashmi, SS, Carroll, MP, Smith, KG, Meulmester, KM, Brown, DL, Jon, C & Mosquera, RA 2015, 'Application of an Asthma Screening Questionnaire in Children with Sickle Cell Disease', Pediatric, Allergy, Immunology, and Pulmonology, vol. 28, no. 3, pp. 177-182. https://doi.org/10.1089/ped.2015.0515
Yadav, Aravind ; Corrales-Medina, Fernando ; Stark, James M. ; Hashmi, S. Shahrukh ; Carroll, Mary P. ; Smith, Keely G. ; Meulmester, Kristen M. ; Brown, Deborah L. ; Jon, Cindy ; Mosquera, Ricardo A. / Application of an Asthma Screening Questionnaire in Children with Sickle Cell Disease. In: Pediatric, Allergy, Immunology, and Pulmonology. 2015 ; Vol. 28, No. 3. pp. 177-182.
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