Apparent diffusion coefficient (ADC) change on repeated diffusion-weighted magnetic resonance imaging during radiochemotherapy for non-small cell lung cancer: A pilot study

Elisabeth Weiss, John Ford, Kathryn M. Olsen, Kishor Karki, Siddharth Saraiya, Robert Groves, Geoffrey D. Hugo

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Objectives: Serial diffusion-weighted magnetic resonance imaging (DW-MRI) during radiochemotherapy of non-small cell lung cancer (NSCLC) is analyzed to investigate the apparent diffusion coefficient (ADC) as a potential biomarker for tumor response. Methods: Ten patients underwent DW-MRI prior to and at three and six weeks during radiochemotherapy. Three methods of contouring primary tumors (PT) were performed to evaluate the impact of tumor heterogeneity on ADC values: PTT: whole tumor volume; PTT-N: PTT-necrosis; PTL: small volume of presumed active tumor with low ADC value. Pretreatment and during-treatment absolute ADC values and ADC value changes were analyzed for PT and involved lymph nodes (LN). Results: ADC values for PTT, PTT-N, PTL and LN increased by 8-14% (PT) and 15% (LN) at three weeks, and 19-26% and 23% at 6 weeks post initial treatment (p = 0.04-0.002). Average percent ADC value increase was smaller than tumor volume regression (p = 0.06-0.0005). Patients with overall survival T). Conclusions: Significant ADC value increases during radiochemotherapy for non-small cell lung cancer were observed. ADC value change during treatment appears to be an independent marker of patient outcome and warrants further investigation.

Original languageEnglish (US)
Pages (from-to)113-119
Number of pages7
JournalLung Cancer
Volume96
DOIs
StatePublished - Jun 1 2016

Keywords

  • Diffusion-weighted MRI
  • Non small cell lung cancer
  • Radiotherapy
  • Response assessment

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

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