Apolipoproteins and carotid artery atherosclerosis in an elderly multiethnic population: The Northern Manhattan stroke study

Jiann Shing Jeng, Ralph L Sacco, Douglas E. Kargman, Bernadette Boden-Albala, Myunghee C. Paik, Jeffrey Jones, Lars Berglund

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The association of apolipoproteins A-I and B (apo A-I and apo B) with cardiovascular disease has been studied in younger populations, but there is sparse information in the elderly. We determined whether apo A-I and apo B were associated with carotid artery atherosclerosis (CAA) in 507 stroke-free elderly community residents (mean age 70.1±11.7 years, 60% women, 41% Hispanics, 30% African American, 28% Caucasian). CAA severity was normal (no plaque or carotid stenosis) in 39%, mild (maximum plaque thickness ≤1.8 mm or carotid stenosis <40%) in 25%, and moderate/severe (maximum plaque thickness >1.8 mm or carotid stenosis ≥40%) in 36%. CAA severity increased with age in all race/ethnic groups (P<0.01). CAA was similar among African Americans and Caucasians, but less in Hispanics (age adjusted OR: 0.5, CI: 0.4-0.8). apo A-I <1.2 g/l (OR: 2.0, CI: 1.0-3.3) and apo B ≥1.4 g/l (OR: 2.0, CI: 1.1-3.6) were associated with moderate-severe CAA. An apo B/apo A-I ratio ≥1 was associated with moderate-severe CAA (OR: 2.4, CI: 1.3-4.4), and the association varied by race (Hispanics OR: 4.3, CI: 1.8-10; non-Hispanics, OR: 1.4, CI: 0.6-3.2). Total cholesterol, triglycerides and low density lipoprotein cholesterol were not associated with moderate-severe CAA, while high density lipoprotein cholesterol was protective (OR: 0.4, CI: 0.2-0.8). Thus, in an elderly population, apo A-I and B were determinants of moderate-severe CAA, and the degree of association varied by race/ethnicity

Original languageEnglish
Pages (from-to)317-325
Number of pages9
JournalAtherosclerosis
Volume165
Issue number2
DOIs
StatePublished - Dec 1 2002
Externally publishedYes

Fingerprint

Carotid Artery Diseases
Apolipoproteins
Carotid Arteries
Apolipoprotein A-I
Apolipoproteins B
Stroke
Population
Carotid Stenosis
Hispanic Americans
African Americans
Ethnic Groups
LDL Cholesterol
HDL Cholesterol
Triglycerides
Cardiovascular Diseases
Cholesterol

Keywords

  • Apolipoprotein
  • Atherosclerosis
  • Carotid arteries
  • Racial differences
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Apolipoproteins and carotid artery atherosclerosis in an elderly multiethnic population : The Northern Manhattan stroke study. / Jeng, Jiann Shing; Sacco, Ralph L; Kargman, Douglas E.; Boden-Albala, Bernadette; Paik, Myunghee C.; Jones, Jeffrey; Berglund, Lars.

In: Atherosclerosis, Vol. 165, No. 2, 01.12.2002, p. 317-325.

Research output: Contribution to journalArticle

Jeng, Jiann Shing ; Sacco, Ralph L ; Kargman, Douglas E. ; Boden-Albala, Bernadette ; Paik, Myunghee C. ; Jones, Jeffrey ; Berglund, Lars. / Apolipoproteins and carotid artery atherosclerosis in an elderly multiethnic population : The Northern Manhattan stroke study. In: Atherosclerosis. 2002 ; Vol. 165, No. 2. pp. 317-325.
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AB - The association of apolipoproteins A-I and B (apo A-I and apo B) with cardiovascular disease has been studied in younger populations, but there is sparse information in the elderly. We determined whether apo A-I and apo B were associated with carotid artery atherosclerosis (CAA) in 507 stroke-free elderly community residents (mean age 70.1±11.7 years, 60% women, 41% Hispanics, 30% African American, 28% Caucasian). CAA severity was normal (no plaque or carotid stenosis) in 39%, mild (maximum plaque thickness ≤1.8 mm or carotid stenosis <40%) in 25%, and moderate/severe (maximum plaque thickness >1.8 mm or carotid stenosis ≥40%) in 36%. CAA severity increased with age in all race/ethnic groups (P<0.01). CAA was similar among African Americans and Caucasians, but less in Hispanics (age adjusted OR: 0.5, CI: 0.4-0.8). apo A-I <1.2 g/l (OR: 2.0, CI: 1.0-3.3) and apo B ≥1.4 g/l (OR: 2.0, CI: 1.1-3.6) were associated with moderate-severe CAA. An apo B/apo A-I ratio ≥1 was associated with moderate-severe CAA (OR: 2.4, CI: 1.3-4.4), and the association varied by race (Hispanics OR: 4.3, CI: 1.8-10; non-Hispanics, OR: 1.4, CI: 0.6-3.2). Total cholesterol, triglycerides and low density lipoprotein cholesterol were not associated with moderate-severe CAA, while high density lipoprotein cholesterol was protective (OR: 0.4, CI: 0.2-0.8). Thus, in an elderly population, apo A-I and B were determinants of moderate-severe CAA, and the degree of association varied by race/ethnicity

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