Apolipoprotein E polymorphism and age of onset for Alzheimer's disease in a bi-ethnic sample

Dylan G. Harwood, Warren W. Barker, Raymond L. Ownby, Peter St. George-Hyslop, Michael Mullan, Ranjan Duara

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: This study examined the association between the Apolipoprotein-E ε4 allele (APOE ε4) and age of disease onset in a bi-ethnic sample of community dwelling Alzheimer's disease (AD) patients. Design: Cross-sectional study of AD patients evaluated at a University-affiliated outpatient memory disorders clinic. Subjects: A clinic-based cohort of white non-Hispanic (WNH; n = 601) and white Hispanic (WH; n = 359) patients diagnosed with possible or probable AD according to NINCDS-ADRDA diagnostic criteria. Measures: Global cognitive functioning of the subjects was evaluated using the Mini-mental State Exam. The age of onset of AD was calculated from the patient's current age minus the reported duration of disease obtained from a knowledgeable family member. Results: A significant relationship was discovered between APOE ε4 and age of onset for WNH, with lower ages of onset among patients carrying the ε4/ε4 and ε3/ε4 genotypes in relation to patients with the ε3/ε3 genotype. The results revealed a more modest effect for APOE genotype in the WH cohort, with a lower age of onset witnessed among ε4 positive patients (ε2/ε4, ε3/ε4 and ε4/ε4 genotypes) in comparison to ε4 negative patients (ε2/ε2, ε2/ε3 and ε3/ε3 genotypes). Conclusion: The association between the ε4 allele and earlier age of onset was more pronounced in WNH compared to WH patients, suggesting the impact of APOE polymorphism on clinical phenotype may be different for distinct ethnic groups in the U.S.

Original languageEnglish
Pages (from-to)317-326
Number of pages10
JournalInternational Psychogeriatrics
Volume16
Issue number3
DOIs
StatePublished - Sep 1 2004
Externally publishedYes

Fingerprint

Apolipoproteins E
Age of Onset
Alzheimer Disease
Genotype
Apolipoprotein E4
Alleles
Independent Living
Memory Disorders
Hispanic Americans
Ethnic Groups
Outpatients
Cross-Sectional Studies
Phenotype

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Aging
  • Psychiatry and Mental health
  • Psychology(all)
  • Clinical Psychology

Cite this

Harwood, D. G., Barker, W. W., Ownby, R. L., St. George-Hyslop, P., Mullan, M., & Duara, R. (2004). Apolipoprotein E polymorphism and age of onset for Alzheimer's disease in a bi-ethnic sample. International Psychogeriatrics, 16(3), 317-326. https://doi.org/10.1017/S104161020400033X

Apolipoprotein E polymorphism and age of onset for Alzheimer's disease in a bi-ethnic sample. / Harwood, Dylan G.; Barker, Warren W.; Ownby, Raymond L.; St. George-Hyslop, Peter; Mullan, Michael; Duara, Ranjan.

In: International Psychogeriatrics, Vol. 16, No. 3, 01.09.2004, p. 317-326.

Research output: Contribution to journalArticle

Harwood, DG, Barker, WW, Ownby, RL, St. George-Hyslop, P, Mullan, M & Duara, R 2004, 'Apolipoprotein E polymorphism and age of onset for Alzheimer's disease in a bi-ethnic sample', International Psychogeriatrics, vol. 16, no. 3, pp. 317-326. https://doi.org/10.1017/S104161020400033X
Harwood, Dylan G. ; Barker, Warren W. ; Ownby, Raymond L. ; St. George-Hyslop, Peter ; Mullan, Michael ; Duara, Ranjan. / Apolipoprotein E polymorphism and age of onset for Alzheimer's disease in a bi-ethnic sample. In: International Psychogeriatrics. 2004 ; Vol. 16, No. 3. pp. 317-326.
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