Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in alzheimer’s disease and in age-matched controls

Seol Heui Han, Christine Hulette, Ann M. Saunders, Gillian Einstein, Margaret Pericak-Vance, Warren J. Strittmatter, Allen D. Roses, Donald E. Schmechel

Research output: Contribution to journalArticlepeer-review

134 Scopus citations

Abstract

Apolipoprotein E (apoE, protein; APOE, gene) is a susceptibility gene for late onset familial and sporadic Alzheimer's disease (AD). To examine the role of apoE in the pathogenesis of AD, we used immunocytochemistry to compare apoE localization in the hippocampus of histologically confirmed cases of AD, Parkinson's disease (PD), and normal controls. We confirmed apoE immunoreactivity in astrocytes, senile plaques, blood vessels, and some neurons containing neurofibrillary tangles (NFTs). In addition, we observed apoE immunereactivity in hippocampal neurons without NFTs in AD and PD patients as well as in some nondemented aged controls, In AD cases, apoE-immunoreactive neurites were closely associated with β-amyloid (Aβ) containing senile plaques and intraneuronal apoE was sometimes associated with immunoreactive tau protein accumulation. Thus, apoE is localized where it may affect the biological expression of two characteristic AD pathological correlates: extracellular Aβ deposition and intraneuronal tau metabolism and NFT formation.

Original languageEnglish (US)
Pages (from-to)13-26
Number of pages14
JournalExperimental neurology
Volume128
Issue number1
DOIs
StatePublished - Jul 1994
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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