Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls

S. H. Han, C. Hulette, A. M. Saunders, G. Einstein, Margaret A Pericak-Vance, W. J. Strittmatter, A. D. Roses, D. E. Schmechel

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

Apolipoprotein E (apoE, protein; APOE, gene) is a susceptibility gene for late onset familial and sporadic Alzheimer's disease (AD). To examine the role of apoE in the pathogenesis of AD, we used immunocytochemistry to compare apoE localization in the hippocampus of histologically confirmed cases of AD, Parkinson's disease (PD), and normal controls. We confirmed apoE immunoreactivity in astrocytes, senile plaques, blood vessels, and some neurons containing neurofibrillary tangles (NFTs). In addition, we observed apoE immunereactivity in hippocampal neurons without NFTs in AD and PD patients as well as in some nondemented aged controls, In AD cases, apoE-immunoreactive neurites were closely associated with β-amyloid (Aβ) containing senile plaques and intraneuronal apoE was sometimes associated with immunoreactive tau protein accumulation. Thus, apoE is localized where it may affect the biological expression of two characteristic AD pathological correlates: extracellular Aβ deposition and intraneuronal tau metabolism and NFT formation.

Original languageEnglish
Pages (from-to)13-26
Number of pages14
JournalExperimental Neurology
Volume128
Issue number1
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Apolipoproteins E
Neurons
Alzheimer Disease
Neurofibrillary Tangles
Amyloid Plaques
Parkinson Disease
Alzheimer's disease without Neurofibrillary tangles
tau Proteins
Neurites
Amyloid
Astrocytes
Blood Vessels
Hippocampus
Immunohistochemistry

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology

Cite this

Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls. / Han, S. H.; Hulette, C.; Saunders, A. M.; Einstein, G.; Pericak-Vance, Margaret A; Strittmatter, W. J.; Roses, A. D.; Schmechel, D. E.

In: Experimental Neurology, Vol. 128, No. 1, 01.01.1994, p. 13-26.

Research output: Contribution to journalArticle

Han, S. H. ; Hulette, C. ; Saunders, A. M. ; Einstein, G. ; Pericak-Vance, Margaret A ; Strittmatter, W. J. ; Roses, A. D. ; Schmechel, D. E. / Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls. In: Experimental Neurology. 1994 ; Vol. 128, No. 1. pp. 13-26.
@article{8a04ae760e864e6fb597589cbe2973a7,
title = "Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls",
abstract = "Apolipoprotein E (apoE, protein; APOE, gene) is a susceptibility gene for late onset familial and sporadic Alzheimer's disease (AD). To examine the role of apoE in the pathogenesis of AD, we used immunocytochemistry to compare apoE localization in the hippocampus of histologically confirmed cases of AD, Parkinson's disease (PD), and normal controls. We confirmed apoE immunoreactivity in astrocytes, senile plaques, blood vessels, and some neurons containing neurofibrillary tangles (NFTs). In addition, we observed apoE immunereactivity in hippocampal neurons without NFTs in AD and PD patients as well as in some nondemented aged controls, In AD cases, apoE-immunoreactive neurites were closely associated with β-amyloid (Aβ) containing senile plaques and intraneuronal apoE was sometimes associated with immunoreactive tau protein accumulation. Thus, apoE is localized where it may affect the biological expression of two characteristic AD pathological correlates: extracellular Aβ deposition and intraneuronal tau metabolism and NFT formation.",
author = "Han, {S. H.} and C. Hulette and Saunders, {A. M.} and G. Einstein and Pericak-Vance, {Margaret A} and Strittmatter, {W. J.} and Roses, {A. D.} and Schmechel, {D. E.}",
year = "1994",
month = "1",
day = "1",
doi = "10.1006/exnr.1994.1108",
language = "English",
volume = "128",
pages = "13--26",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls

AU - Han, S. H.

AU - Hulette, C.

AU - Saunders, A. M.

AU - Einstein, G.

AU - Pericak-Vance, Margaret A

AU - Strittmatter, W. J.

AU - Roses, A. D.

AU - Schmechel, D. E.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Apolipoprotein E (apoE, protein; APOE, gene) is a susceptibility gene for late onset familial and sporadic Alzheimer's disease (AD). To examine the role of apoE in the pathogenesis of AD, we used immunocytochemistry to compare apoE localization in the hippocampus of histologically confirmed cases of AD, Parkinson's disease (PD), and normal controls. We confirmed apoE immunoreactivity in astrocytes, senile plaques, blood vessels, and some neurons containing neurofibrillary tangles (NFTs). In addition, we observed apoE immunereactivity in hippocampal neurons without NFTs in AD and PD patients as well as in some nondemented aged controls, In AD cases, apoE-immunoreactive neurites were closely associated with β-amyloid (Aβ) containing senile plaques and intraneuronal apoE was sometimes associated with immunoreactive tau protein accumulation. Thus, apoE is localized where it may affect the biological expression of two characteristic AD pathological correlates: extracellular Aβ deposition and intraneuronal tau metabolism and NFT formation.

AB - Apolipoprotein E (apoE, protein; APOE, gene) is a susceptibility gene for late onset familial and sporadic Alzheimer's disease (AD). To examine the role of apoE in the pathogenesis of AD, we used immunocytochemistry to compare apoE localization in the hippocampus of histologically confirmed cases of AD, Parkinson's disease (PD), and normal controls. We confirmed apoE immunoreactivity in astrocytes, senile plaques, blood vessels, and some neurons containing neurofibrillary tangles (NFTs). In addition, we observed apoE immunereactivity in hippocampal neurons without NFTs in AD and PD patients as well as in some nondemented aged controls, In AD cases, apoE-immunoreactive neurites were closely associated with β-amyloid (Aβ) containing senile plaques and intraneuronal apoE was sometimes associated with immunoreactive tau protein accumulation. Thus, apoE is localized where it may affect the biological expression of two characteristic AD pathological correlates: extracellular Aβ deposition and intraneuronal tau metabolism and NFT formation.

UR - http://www.scopus.com/inward/record.url?scp=0028018114&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028018114&partnerID=8YFLogxK

U2 - 10.1006/exnr.1994.1108

DO - 10.1006/exnr.1994.1108

M3 - Article

C2 - 8070517

AN - SCOPUS:0028018114

VL - 128

SP - 13

EP - 26

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

IS - 1

ER -