Apolipoprotein E genotype and cognitive impairment in community-dwelling black older adults

Dylan G. Harwood, Warren W. Barker, Raymond L. Ownby, Michael Mullan, Ranjan Duara

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: The relationship between the epsilon 4 allele of the apolipoprotein E gene (APOE-ε4) located on chromosome 19 and Alzheimer's disease is well documented among Caucasian populations. However, the findings of research addressing the link between APOE polymorphism and neurocognitive functioning in populations of African origin from around the world have been equivocal. Therefore, the current study explored the relation of APOE-ε4 with cognitive impairment in a sample of community-dwelling English-speaking elderly blacks. Methods: All participants (N = 57) were recruited consecutively from a community memory-screening program at a University affiliated Memory Disorders Clinic and evaluated using standardized assessment procedures. Cognitive impairment was classified according to an age and education adjusted Mini-Mental State Exam score of less than 24 as well as poorer functioning on a measure of delayed verbal memory. Results: Increased risk for global cognitive dysfunction (OR = 9.5, 95 percent CI = 2.3-55.3, p = .004) and poorer verbal recall performance (β = -.36 p = .006) were linked with the APOE ε4 allele after controlling for the potentially confounding effects of age, education, and gender. Conclusions: This investigation supports the role of APOE polymorphism in determining neurocognitive impairment among black elders residing in the community.

Original languageEnglish
Pages (from-to)55-67
Number of pages13
JournalInternational Journal of Psychiatry in Medicine
Volume32
Issue number1
DOIs
StatePublished - Jun 19 2002
Externally publishedYes

Fingerprint

Independent Living
Apolipoproteins E
Genotype
Sambucus nigra
Alleles
Repression (Psychology)
Apolipoprotein E4
Chromosomes, Human, Pair 19
Education
Memory Disorders
Population
Alzheimer Disease
Research
Genes
Cognitive Dysfunction

Keywords

  • APOE
  • Blacks
  • Cognitive impairment
  • Dementia

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Apolipoprotein E genotype and cognitive impairment in community-dwelling black older adults. / Harwood, Dylan G.; Barker, Warren W.; Ownby, Raymond L.; Mullan, Michael; Duara, Ranjan.

In: International Journal of Psychiatry in Medicine, Vol. 32, No. 1, 19.06.2002, p. 55-67.

Research output: Contribution to journalArticle

Harwood, Dylan G. ; Barker, Warren W. ; Ownby, Raymond L. ; Mullan, Michael ; Duara, Ranjan. / Apolipoprotein E genotype and cognitive impairment in community-dwelling black older adults. In: International Journal of Psychiatry in Medicine. 2002 ; Vol. 32, No. 1. pp. 55-67.
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