Apolipoprotein-E (APO-E) genotype and symptoms of psychosis in Alzheimer's disease

Dylan G. Harwood, Warren W. Barker, Raymond L. Ownby, Peter St. George-Hyslop, Ranjan Duara

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The authors examined the association of Apolipoprotein-E (APO-E) genotype to symptoms of psychosis and depression in 501 patients diagnosed with probable (n = 343) or possible (n = 158) Alzheimer's disease (AD) according to NINCDS-ADRDA criteria. They observed the following APO-E genotypes: ε2/ε3 (n = 19); ε2/ε4 (n = 14); ε3/ε3 (n = 228); ε3/ε4 (n = 203); ε4/ε4 (n = 37). In contrast to previous reports, the results did not indicate a relationship between either the ε4 allele or the ε2 allele and symptoms of mood disturbance in AD. However, an elevated risk for psychosis was shown, specifically, at the severe stage of cognitive impairment, among AD patients carrying the ε4 allele, after effects of age, gender, education, and level of cognitive impairment were controlled.

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalAmerican Journal of Geriatric Psychiatry
Volume7
Issue number2
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

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Apolipoproteins E
Psychotic Disorders
Alzheimer Disease
Alleles
Genotype
Apolipoprotein E2
Depression
Education
Cognitive Dysfunction

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology

Cite this

Apolipoprotein-E (APO-E) genotype and symptoms of psychosis in Alzheimer's disease. / Harwood, Dylan G.; Barker, Warren W.; Ownby, Raymond L.; St. George-Hyslop, Peter; Duara, Ranjan.

In: American Journal of Geriatric Psychiatry, Vol. 7, No. 2, 01.01.1999, p. 119-123.

Research output: Contribution to journalArticle

Harwood, Dylan G. ; Barker, Warren W. ; Ownby, Raymond L. ; St. George-Hyslop, Peter ; Duara, Ranjan. / Apolipoprotein-E (APO-E) genotype and symptoms of psychosis in Alzheimer's disease. In: American Journal of Geriatric Psychiatry. 1999 ; Vol. 7, No. 2. pp. 119-123.
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