Apolipoprotein-E (APO-E) genotype and symptoms of psychosis in Alzheimer's disease

Dylan G. Harwood, Warren W. Barker, Raymond L. Ownby, Peter St. George-Hyslop, Ranjan Duara

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52 Scopus citations


The authors examined the association of Apolipoprotein-E (APO-E) genotype to symptoms of psychosis and depression in 501 patients diagnosed with probable (n = 343) or possible (n = 158) Alzheimer's disease (AD) according to NINCDS-ADRDA criteria. They observed the following APO-E genotypes: ε2/ε3 (n = 19); ε2/ε4 (n = 14); ε3/ε3 (n = 228); ε3/ε4 (n = 203); ε4/ε4 (n = 37). In contrast to previous reports, the results did not indicate a relationship between either the ε4 allele or the ε2 allele and symptoms of mood disturbance in AD. However, an elevated risk for psychosis was shown, specifically, at the severe stage of cognitive impairment, among AD patients carrying the ε4 allele, after effects of age, gender, education, and level of cognitive impairment were controlled.

Original languageEnglish (US)
Pages (from-to)119-123
Number of pages5
JournalAmerican Journal of Geriatric Psychiatry
Issue number2
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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