Apolipoprotein E ε2 does not increase risk of early-onset sporadic Alzheimer's disease

W. K. Scott; A. M. Saunders; P. C. Gaskell; P. A. Locke; J. H. Growdon; L. A. Farrer; S. A. Auerbach; A. D. Roses; J. L. Haines; M. A. Pericak-Vance

doi:10.1002/ana.410420317

Apolipoprotein E ε2 does not increase risk of early-onset sporadic Alzheimer's disease

W. K. Scott, A. M. Saunders, P. C. Gaskell, P. A. Locke, J. H. Growdon, L. A. Farrer, S. A. Auerbach, A. D. Roses, J. L. Haines, M. A. Pericak-Vance

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

We examined the association of apolipoprotein E (ApoE) genotype and the risk of early-onset Alzheimer's disease (AD) in 209 white early-onset sporadic cases (43% male) and 303 white controls (48% male) of similar age distribution. The risk of AD was significantly increased, relative to the 3/3 genotype, in people with the 4/4, 3/4, and 2/4 genotypes, controlling for age at time of examination and sex. The 2/3 genotype reduced slightly the risk of AD, although the effect was not statistically significant. We conclude, contrary to some previous reports, that the ApoE ε2 allele does not increase the risk of early-onset sporadic AD.

Original language	English (US)
Pages (from-to)	376-378
Number of pages	3
Journal	Annals of neurology
Volume	42
Issue number	3
DOIs	https://doi.org/10.1002/ana.410420317
State	Published - Sep 1997
Externally published	Yes

ASJC Scopus subject areas

Neurology
Clinical Neurology

Access to Document

10.1002/ana.410420317

Cite this

Apolipoprotein E ε2 does not increase risk of early-onset sporadic Alzheimer's disease. / Scott, W. K.; Saunders, A. M.; Gaskell, P. C.; Locke, P. A.; Growdon, J. H.; Farrer, L. A.; Auerbach, S. A.; Roses, A. D.; Haines, J. L.; Pericak-Vance, M. A.

In: Annals of neurology, Vol. 42, No. 3, 09.1997, p. 376-378.

Research output: Contribution to journal › Article › peer-review

@article{84cc7b0ffbae4d689543e43d7b0c6568,

title = "Apolipoprotein E ε2 does not increase risk of early-onset sporadic Alzheimer's disease",

abstract = "We examined the association of apolipoprotein E (ApoE) genotype and the risk of early-onset Alzheimer's disease (AD) in 209 white early-onset sporadic cases (43% male) and 303 white controls (48% male) of similar age distribution. The risk of AD was significantly increased, relative to the 3/3 genotype, in people with the 4/4, 3/4, and 2/4 genotypes, controlling for age at time of examination and sex. The 2/3 genotype reduced slightly the risk of AD, although the effect was not statistically significant. We conclude, contrary to some previous reports, that the ApoE ε2 allele does not increase the risk of early-onset sporadic AD.",

author = "Scott, {W. K.} and Saunders, {A. M.} and Gaskell, {P. C.} and Locke, {P. A.} and Growdon, {J. H.} and Farrer, {L. A.} and Auerbach, {S. A.} and Roses, {A. D.} and Haines, {J. L.} and Pericak-Vance, {M. A.}",

year = "1997",

month = sep,

doi = "10.1002/ana.410420317",

language = "English (US)",

volume = "42",

pages = "376--378",

journal = "Annals of Neurology",

issn = "0364-5134",

publisher = "John Wiley and Sons Inc.",

number = "3",

}

TY - JOUR

T1 - Apolipoprotein E ε2 does not increase risk of early-onset sporadic Alzheimer's disease

AU - Scott, W. K.

AU - Saunders, A. M.

AU - Gaskell, P. C.

AU - Locke, P. A.

AU - Growdon, J. H.

AU - Farrer, L. A.

AU - Auerbach, S. A.

AU - Roses, A. D.

AU - Haines, J. L.

AU - Pericak-Vance, M. A.

PY - 1997/9

Y1 - 1997/9

N2 - We examined the association of apolipoprotein E (ApoE) genotype and the risk of early-onset Alzheimer's disease (AD) in 209 white early-onset sporadic cases (43% male) and 303 white controls (48% male) of similar age distribution. The risk of AD was significantly increased, relative to the 3/3 genotype, in people with the 4/4, 3/4, and 2/4 genotypes, controlling for age at time of examination and sex. The 2/3 genotype reduced slightly the risk of AD, although the effect was not statistically significant. We conclude, contrary to some previous reports, that the ApoE ε2 allele does not increase the risk of early-onset sporadic AD.

AB - We examined the association of apolipoprotein E (ApoE) genotype and the risk of early-onset Alzheimer's disease (AD) in 209 white early-onset sporadic cases (43% male) and 303 white controls (48% male) of similar age distribution. The risk of AD was significantly increased, relative to the 3/3 genotype, in people with the 4/4, 3/4, and 2/4 genotypes, controlling for age at time of examination and sex. The 2/3 genotype reduced slightly the risk of AD, although the effect was not statistically significant. We conclude, contrary to some previous reports, that the ApoE ε2 allele does not increase the risk of early-onset sporadic AD.

UR - http://www.scopus.com/inward/record.url?scp=0030612492&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030612492&partnerID=8YFLogxK

U2 - 10.1002/ana.410420317

DO - 10.1002/ana.410420317

M3 - Article

C2 - 9307262

AN - SCOPUS:0030612492

VL - 42

SP - 376

EP - 378

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 3

ER -

Apolipoprotein E ε2 does not increase risk of early-onset sporadic Alzheimer's disease

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this