Apolipoprotein E ε2 does not increase risk of early-onset sporadic Alzheimer's disease

W. K. Scott; A. M. Saunders; P. C. Gaskell; P. A. Locke; J. H. Growdon; L. A. Farrer; S. A. Auerbach; A. D. Roses; J. L. Haines; M. A. Pericak-Vance

doi:10.1002/ana.410420317

Apolipoprotein E ε2 does not increase risk of early-onset sporadic Alzheimer's disease

W. K. Scott, A. M. Saunders, P. C. Gaskell, P. A. Locke, J. H. Growdon, L. A. Farrer, S. A. Auerbach, A. D. Roses, J. L. Haines, M. A. Pericak-Vance

Research output: Contribution to journal › Article › peer-review

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Abstract

We examined the association of apolipoprotein E (ApoE) genotype and the risk of early-onset Alzheimer's disease (AD) in 209 white early-onset sporadic cases (43% male) and 303 white controls (48% male) of similar age distribution. The risk of AD was significantly increased, relative to the 3/3 genotype, in people with the 4/4, 3/4, and 2/4 genotypes, controlling for age at time of examination and sex. The 2/3 genotype reduced slightly the risk of AD, although the effect was not statistically significant. We conclude, contrary to some previous reports, that the ApoE ε2 allele does not increase the risk of early-onset sporadic AD.

Original language	English (US)
Pages (from-to)	376-378
Number of pages	3
Journal	Annals of neurology
Volume	42
Issue number	3
DOIs	https://doi.org/10.1002/ana.410420317
State	Published - Sep 1997
Externally published	Yes

ASJC Scopus subject areas

Neurology
Clinical Neurology

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Apolipoprotein E ε2 does not increase risk of early-onset sporadic Alzheimer's disease. / Scott, W. K.; Saunders, A. M.; Gaskell, P. C.; Locke, P. A.; Growdon, J. H.; Farrer, L. A.; Auerbach, S. A.; Roses, A. D.; Haines, J. L.; Pericak-Vance, M. A.

In: Annals of neurology, Vol. 42, No. 3, 09.1997, p. 376-378.

Research output: Contribution to journal › Article › peer-review

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AU - Scott, W. K.

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AU - Gaskell, P. C.

AU - Locke, P. A.

AU - Growdon, J. H.

AU - Farrer, L. A.

AU - Auerbach, S. A.

AU - Roses, A. D.

AU - Haines, J. L.

AU - Pericak-Vance, M. A.

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AB - We examined the association of apolipoprotein E (ApoE) genotype and the risk of early-onset Alzheimer's disease (AD) in 209 white early-onset sporadic cases (43% male) and 303 white controls (48% male) of similar age distribution. The risk of AD was significantly increased, relative to the 3/3 genotype, in people with the 4/4, 3/4, and 2/4 genotypes, controlling for age at time of examination and sex. The 2/3 genotype reduced slightly the risk of AD, although the effect was not statistically significant. We conclude, contrary to some previous reports, that the ApoE ε2 allele does not increase the risk of early-onset sporadic AD.

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Apolipoprotein E ε2 does not increase risk of early-onset sporadic Alzheimer's disease

Abstract

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