Abstract
We examined the association of apolipoprotein E (ApoE) genotype and the risk of early-onset Alzheimer's disease (AD) in 209 white early-onset sporadic cases (43% male) and 303 white controls (48% male) of similar age distribution. The risk of AD was significantly increased, relative to the 3/3 genotype, in people with the 4/4, 3/4, and 2/4 genotypes, controlling for age at time of examination and sex. The 2/3 genotype reduced slightly the risk of AD, although the effect was not statistically significant. We conclude, contrary to some previous reports, that the ApoE ε2 allele does not increase the risk of early-onset sporadic AD.
| Original language | English |
|---|---|
| Pages (from-to) | 376-378 |
| Number of pages | 3 |
| Journal | Annals of Neurology |
| Volume | 42 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1 1997 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
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Apolipoprotein E ε2 does not increase risk of early-onset sporadic Alzheimer's disease. / Scott, William K; Saunders, A. M.; Gaskell, P. C.; Locke, P. A.; Growdon, J. H.; Farrer, L. A.; Auerbach, S. A.; Roses, A. D.; Haines, J. L.; Pericak-Vance, Margaret A.
In: Annals of Neurology, Vol. 42, No. 3, 01.09.1997, p. 376-378.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Apolipoprotein E ε2 does not increase risk of early-onset sporadic Alzheimer's disease
AU - Scott, William K
AU - Saunders, A. M.
AU - Gaskell, P. C.
AU - Locke, P. A.
AU - Growdon, J. H.
AU - Farrer, L. A.
AU - Auerbach, S. A.
AU - Roses, A. D.
AU - Haines, J. L.
AU - Pericak-Vance, Margaret A
PY - 1997/9/1
Y1 - 1997/9/1
N2 - We examined the association of apolipoprotein E (ApoE) genotype and the risk of early-onset Alzheimer's disease (AD) in 209 white early-onset sporadic cases (43% male) and 303 white controls (48% male) of similar age distribution. The risk of AD was significantly increased, relative to the 3/3 genotype, in people with the 4/4, 3/4, and 2/4 genotypes, controlling for age at time of examination and sex. The 2/3 genotype reduced slightly the risk of AD, although the effect was not statistically significant. We conclude, contrary to some previous reports, that the ApoE ε2 allele does not increase the risk of early-onset sporadic AD.
AB - We examined the association of apolipoprotein E (ApoE) genotype and the risk of early-onset Alzheimer's disease (AD) in 209 white early-onset sporadic cases (43% male) and 303 white controls (48% male) of similar age distribution. The risk of AD was significantly increased, relative to the 3/3 genotype, in people with the 4/4, 3/4, and 2/4 genotypes, controlling for age at time of examination and sex. The 2/3 genotype reduced slightly the risk of AD, although the effect was not statistically significant. We conclude, contrary to some previous reports, that the ApoE ε2 allele does not increase the risk of early-onset sporadic AD.
UR - http://www.scopus.com/inward/record.url?scp=0030612492&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030612492&partnerID=8YFLogxK
U2 - 10.1002/ana.410420317
DO - 10.1002/ana.410420317
M3 - Article
C2 - 9307262
AN - SCOPUS:0030612492
VL - 42
SP - 376
EP - 378
JO - Annals of Neurology
JF - Annals of Neurology
SN - 0364-5134
IS - 3
ER -