Apolipoprotein B-100 XbaI gene polymorphism in gallbladder cancer

Mahendra Singh, Udai Bhan Pandey, Uday Chand Ghoshal, Itha Srivenu, Vinay Kumar Kapoor, Gourdas Choudhuri, Balraj Mittal

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Genetic polymorphisms in the apolipoprotein B (apoB) gene have been reported to be associated with altered serum lipids and susceptibility to cholesterol gallstones (GS). Gallstones are among the well-known risk factors for carcinoma of the gallbladder (GBQ. In the present study, the association between the XbaI polymorphism of the apo B gene was examined in patients with GBC and GS and in normal controls in a north Indian population. DNA samples from patients with GBC (n=153), GS (n=117) and healthy subjects (n=137) were analysed for the apoB-XbaI polymorphism by polymerase chain reaction followed by restriction fragment length polymorphism. The genotype X+/- was less frequent in patients with GBC (39.2%) than in those with GS (68.3%) and in normal subjects (66.4%; P<0.00001). In contrast, there was an increase in the homozygous X-/- genotype in patients with GBC (54.9%) as compared with those with GS (23.9%) and normal subjects (25.5%; P<0.00001). The frequency of the X- allele was found to be significantly increased in GBC patients with or without GS (odds ratio=2.3 and 1.7, respectively). We suggest that the apoB-XbaI gene polymorphism confers susceptibility to carcinoma of the gallbladder under specific environmental conditions.

Original languageEnglish (US)
Pages (from-to)280-283
Number of pages4
JournalHuman Genetics
Volume114
Issue number3
DOIs
StatePublished - Feb 1 2004
Externally publishedYes

Fingerprint

Apolipoprotein B-100
Gallbladder Neoplasms
Gallstones
Apolipoproteins B
Genes
Gallbladder
Genotype
Carcinoma
Genetic Polymorphisms
Gene Frequency
Restriction Fragment Length Polymorphisms
Healthy Volunteers
Odds Ratio
Cholesterol
Lipids
Polymerase Chain Reaction
DNA
Serum

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Singh, M., Pandey, U. B., Ghoshal, U. C., Srivenu, I., Kapoor, V. K., Choudhuri, G., & Mittal, B. (2004). Apolipoprotein B-100 XbaI gene polymorphism in gallbladder cancer. Human Genetics, 114(3), 280-283. https://doi.org/10.1007/s00439-003-1056-8

Apolipoprotein B-100 XbaI gene polymorphism in gallbladder cancer. / Singh, Mahendra; Pandey, Udai Bhan; Ghoshal, Uday Chand; Srivenu, Itha; Kapoor, Vinay Kumar; Choudhuri, Gourdas; Mittal, Balraj.

In: Human Genetics, Vol. 114, No. 3, 01.02.2004, p. 280-283.

Research output: Contribution to journalArticle

Singh, M, Pandey, UB, Ghoshal, UC, Srivenu, I, Kapoor, VK, Choudhuri, G & Mittal, B 2004, 'Apolipoprotein B-100 XbaI gene polymorphism in gallbladder cancer', Human Genetics, vol. 114, no. 3, pp. 280-283. https://doi.org/10.1007/s00439-003-1056-8
Singh M, Pandey UB, Ghoshal UC, Srivenu I, Kapoor VK, Choudhuri G et al. Apolipoprotein B-100 XbaI gene polymorphism in gallbladder cancer. Human Genetics. 2004 Feb 1;114(3):280-283. https://doi.org/10.1007/s00439-003-1056-8
Singh, Mahendra ; Pandey, Udai Bhan ; Ghoshal, Uday Chand ; Srivenu, Itha ; Kapoor, Vinay Kumar ; Choudhuri, Gourdas ; Mittal, Balraj. / Apolipoprotein B-100 XbaI gene polymorphism in gallbladder cancer. In: Human Genetics. 2004 ; Vol. 114, No. 3. pp. 280-283.
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