Abstract
Background: Although an association between the apolipoprotein E (APOE) e4 allele and increased risk of Alzheimers disease (AD) is established, the utility of APOE genotyping in the clinical diagnosis of AD is still under investigation. Methods: Medical records of 89 patients with cognitive impairment and APOE genotype data underwent a retrospective review. Results: Comparison of age, age at onset, education, Mini-Mental State Examination, months of follow-up, and family history of dementia did not reveal statistical difference among the patients with different APOE genotypes. The APOE ε4 carriers had a higher percentage of AD diagnoses after a median 16 months follow-up than non-APOE ε4 carriers. The APOE e4 designation had a high sensitivity and high positive predictive value for the diagnosis of AD but a low negative predictive value and specificity. Conclusions: The APOE genotyping may be helpful in diagnosing AD especially in patients presenting with atypical features or early age of onset of dementia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 315-320 |
| Number of pages | 6 |
| Journal | American Journal of Alzheimer's Disease and other Dementias |
| Volume | 27 |
| Issue number | 5 |
| DOIs | |
| State | Published - Aug 2012 |
| Externally published | Yes |
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Keywords
- Alzheimer's disease
- APOE
- APOE ?4
- positive predictive value
- sensitivity
ASJC Scopus subject areas
- Psychiatry and Mental health
- Geriatrics and Gerontology
- Clinical Psychology
Cite this
APOE genotype in the diagnosis of Alzheimer's disease in patients with cognitive impairment. / Sun, Xiaoyan; Nicholas, Joyce; Walker, Aljoeson; Wagner, Mark T.; Bachman, David.
In: American Journal of Alzheimer's Disease and other Dementias, Vol. 27, No. 5, 08.2012, p. 315-320.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - APOE genotype in the diagnosis of Alzheimer's disease in patients with cognitive impairment
AU - Sun, Xiaoyan
AU - Nicholas, Joyce
AU - Walker, Aljoeson
AU - Wagner, Mark T.
AU - Bachman, David
PY - 2012/8
Y1 - 2012/8
N2 - Background: Although an association between the apolipoprotein E (APOE) e4 allele and increased risk of Alzheimers disease (AD) is established, the utility of APOE genotyping in the clinical diagnosis of AD is still under investigation. Methods: Medical records of 89 patients with cognitive impairment and APOE genotype data underwent a retrospective review. Results: Comparison of age, age at onset, education, Mini-Mental State Examination, months of follow-up, and family history of dementia did not reveal statistical difference among the patients with different APOE genotypes. The APOE ε4 carriers had a higher percentage of AD diagnoses after a median 16 months follow-up than non-APOE ε4 carriers. The APOE e4 designation had a high sensitivity and high positive predictive value for the diagnosis of AD but a low negative predictive value and specificity. Conclusions: The APOE genotyping may be helpful in diagnosing AD especially in patients presenting with atypical features or early age of onset of dementia.
AB - Background: Although an association between the apolipoprotein E (APOE) e4 allele and increased risk of Alzheimers disease (AD) is established, the utility of APOE genotyping in the clinical diagnosis of AD is still under investigation. Methods: Medical records of 89 patients with cognitive impairment and APOE genotype data underwent a retrospective review. Results: Comparison of age, age at onset, education, Mini-Mental State Examination, months of follow-up, and family history of dementia did not reveal statistical difference among the patients with different APOE genotypes. The APOE ε4 carriers had a higher percentage of AD diagnoses after a median 16 months follow-up than non-APOE ε4 carriers. The APOE e4 designation had a high sensitivity and high positive predictive value for the diagnosis of AD but a low negative predictive value and specificity. Conclusions: The APOE genotyping may be helpful in diagnosing AD especially in patients presenting with atypical features or early age of onset of dementia.
KW - Alzheimer's disease
KW - APOE
KW - APOE ?4
KW - positive predictive value
KW - sensitivity
UR - http://www.scopus.com/inward/record.url?scp=84864185673&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864185673&partnerID=8YFLogxK
U2 - 10.1177/1533317512452037
DO - 10.1177/1533317512452037
M3 - Article
C2 - 22815080
AN - SCOPUS:84864185673
VL - 27
SP - 315
EP - 320
JO - American Journal of Alzheimer's Disease and other Dementias
JF - American Journal of Alzheimer's Disease and other Dementias
SN - 1533-3175
IS - 5
ER -