Abstract
Background: Although an association between the apolipoprotein E (APOE) e4 allele and increased risk of Alzheimers disease (AD) is established, the utility of APOE genotyping in the clinical diagnosis of AD is still under investigation. Methods: Medical records of 89 patients with cognitive impairment and APOE genotype data underwent a retrospective review. Results: Comparison of age, age at onset, education, Mini-Mental State Examination, months of follow-up, and family history of dementia did not reveal statistical difference among the patients with different APOE genotypes. The APOE ε4 carriers had a higher percentage of AD diagnoses after a median 16 months follow-up than non-APOE ε4 carriers. The APOE e4 designation had a high sensitivity and high positive predictive value for the diagnosis of AD but a low negative predictive value and specificity. Conclusions: The APOE genotyping may be helpful in diagnosing AD especially in patients presenting with atypical features or early age of onset of dementia.
Original language | English (US) |
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Pages (from-to) | 315-320 |
Number of pages | 6 |
Journal | American Journal of Alzheimer's Disease and other Dementias |
Volume | 27 |
Issue number | 5 |
DOIs | |
State | Published - Aug 2012 |
Externally published | Yes |
Keywords
- APOE
- APOE ?4
- Alzheimer's disease
- positive predictive value
- sensitivity
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Psychology
- Geriatrics and Gerontology
- Psychiatry and Mental health