Apo J and Apo D: Complementary or Antagonistic Roles in Alzheimer's Disease?

Eva Del Valle, Ana Navarro, Eva Martínez-Pinilla, Silvia Torices, Jorge Tolivia, Yu Zhang

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Apolipoprotein D (Apo D) and Apolipoprotein J (Apo J) are among the only nine apolipoproteins synthesized in the nervous system. Apart from development, these apolipoproteins are implicated in the normal aging process as well as in different neuropathologies as Alzheimer's disease (AD), where a neuroprotective role has been postulated. Different authors have proposed that Apo D and Apo J could be biomarkers for AD but as far as we know, there are no studies about the relationship between them as well as their expression pattern along the progression of the disease. In this paper, using double immunohistochemistry techniques, we have demonstrated that Apo D is mainly located in glial cells while Apo J expression preferentially occurs in neurons; both proteins are also present in AD diffuse and mature senile plaques but without signal overlap. In addition, we have observed that Apo J and Apo D immunostaining shows a positive correlation with the progression of the disease and the Braak's stages. These results suggest complementary and cell-dependent neuroprotective roles for each apolipoprotein during AD progress.

Original languageEnglish (US)
Pages (from-to)639-650
Number of pages12
JournalJournal of Alzheimer's Disease
Issue number2
StatePublished - 2016
Externally publishedYes


  • Amyloid-β peptide
  • Apolipoproteins
  • Braak's stage
  • Frontal cortex
  • Glia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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