Aplastic anemia and pesticides: An etiologic association?

L. E. Fleming, W. Timmeny

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The majority of cases of aplastic anemia, a rare previously lethal disease, are of unknown etiology. Nevertheless, for the past 3 decades, case reports and case series of aplastic anemia have suggested an etiologic association between aplastic anemia and pesticide exposure. A review of the medical literature, including basic science literature, confirms a possible etiologic association between pesticide exposure and aplastic anemia. Two hundred and eighty cases of aplastic anemia associated with pesticide exposure were reported in the literature. The majority of these cases were young (mean age, 34 years; median, 28), with a short latency (mean, 5 months) and with a history of occupational exposure to pesticides. The pesticide exposures reported were the organochlorines and organophosphates, both commonly used pesticides throughout the world. Therapeutic and methodologic issues as well as future directions for research into this etiologic association are discussed.

Original languageEnglish
Pages (from-to)1106-1116
Number of pages11
JournalJournal of Occupational Medicine
Volume35
Issue number11
StatePublished - Jan 1 1993
Externally publishedYes

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Aplastic Anemia
Pesticides
Organophosphates
Occupational Exposure
Research

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Fleming, L. E., & Timmeny, W. (1993). Aplastic anemia and pesticides: An etiologic association? Journal of Occupational Medicine, 35(11), 1106-1116.

Aplastic anemia and pesticides : An etiologic association? / Fleming, L. E.; Timmeny, W.

In: Journal of Occupational Medicine, Vol. 35, No. 11, 01.01.1993, p. 1106-1116.

Research output: Contribution to journalArticle

Fleming, LE & Timmeny, W 1993, 'Aplastic anemia and pesticides: An etiologic association?', Journal of Occupational Medicine, vol. 35, no. 11, pp. 1106-1116.
Fleming, L. E. ; Timmeny, W. / Aplastic anemia and pesticides : An etiologic association?. In: Journal of Occupational Medicine. 1993 ; Vol. 35, No. 11. pp. 1106-1116.
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