Aortic valve calcification in mild primary hyperparathyroidism

Shinichi Iwata, Marcella Donovan Walker, Marco R. Di Tullio, Eiichi Hyodo, Zhezhen Jin, Rui Liu, Ralph L Sacco, Shunichi Homma, Shonni J. Silverberg

Research output: Contribution to journalArticle

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Abstract

Context: It is unclear whether cardiovascular disease is present in primary hyperparathyroidism (PHPT). Objective: Aortic valve structure and function were compared in PHPT patients and populationbased controls. Design: This is a case-control study. Setting: The study was conducted in a university hospital metabolic bone disease unit. Participants: We studied 51 patients with PHPT and 49 controls. Outcome Measures: We measured the aortic valve calcification area and the transaortic pressure gradient. Results: Aortic valve calcification area was significantly higher in PHPT (0.24 ± 0.02 vs. 0.17 ± 0.02 cm 2, p<0.01), although there was no difference in the peak transaortic pressure gradient, a functional measure of valvular calcification (5.6 ± 0.3 vs. 6.0 ± 0.3 mm Hg, P = 0.39). Aortic valve calcification area was positively associated with PTH (r=0.34; P<0.05) but not with serum calcium, phosphorus, or 25-hydroxyvitamin D levels or with calcium-phosphate product. Serum PTH level remained an independent predictor of aortic valve calcification area after adjustment for age, sex, bodymass index,smokingstatus, history of hypercholesterolemiaandhypertension,andestimated glomerular filtration rate. Conclusions: Mild PHPT is associated with subclinical aortic valve calcification. PTH, but not serum calcium concentration, predicted aortic valve calcification. PTH was a more important predictor of aortic valve calcification than well-accepted cardiovascular risk factors.

Original languageEnglish
Pages (from-to)132-137
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume97
Issue number1
DOIs
StatePublished - Jan 1 2012

Fingerprint

Primary Hyperparathyroidism
Pressure gradient
Calcium
Phosphorus
Bone
Serum
Pressure
Metabolic Bone Diseases
Calcification of Aortic Valve
Glomerular Filtration Rate
Aortic Valve
Case-Control Studies
Cardiovascular Diseases
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Iwata, S., Walker, M. D., Di Tullio, M. R., Hyodo, E., Jin, Z., Liu, R., ... Silverberg, S. J. (2012). Aortic valve calcification in mild primary hyperparathyroidism. Journal of Clinical Endocrinology and Metabolism, 97(1), 132-137. https://doi.org/10.1210/jc.2011-2107

Aortic valve calcification in mild primary hyperparathyroidism. / Iwata, Shinichi; Walker, Marcella Donovan; Di Tullio, Marco R.; Hyodo, Eiichi; Jin, Zhezhen; Liu, Rui; Sacco, Ralph L; Homma, Shunichi; Silverberg, Shonni J.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 97, No. 1, 01.01.2012, p. 132-137.

Research output: Contribution to journalArticle

Iwata, S, Walker, MD, Di Tullio, MR, Hyodo, E, Jin, Z, Liu, R, Sacco, RL, Homma, S & Silverberg, SJ 2012, 'Aortic valve calcification in mild primary hyperparathyroidism', Journal of Clinical Endocrinology and Metabolism, vol. 97, no. 1, pp. 132-137. https://doi.org/10.1210/jc.2011-2107
Iwata, Shinichi ; Walker, Marcella Donovan ; Di Tullio, Marco R. ; Hyodo, Eiichi ; Jin, Zhezhen ; Liu, Rui ; Sacco, Ralph L ; Homma, Shunichi ; Silverberg, Shonni J. / Aortic valve calcification in mild primary hyperparathyroidism. In: Journal of Clinical Endocrinology and Metabolism. 2012 ; Vol. 97, No. 1. pp. 132-137.
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