Aortic valve calcification in mild primary hyperparathyroidism

Shinichi Iwata, Marcella Donovan Walker, Marco R. Di Tullio, Eiichi Hyodo, Zhezhen Jin, Rui Liu, Ralph L. Sacco, Shunichi Homma, Shonni J. Silverberg

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


Context: It is unclear whether cardiovascular disease is present in primary hyperparathyroidism (PHPT). Objective: Aortic valve structure and function were compared in PHPT patients and populationbased controls. Design: This is a case-control study. Setting: The study was conducted in a university hospital metabolic bone disease unit. Participants: We studied 51 patients with PHPT and 49 controls. Outcome Measures: We measured the aortic valve calcification area and the transaortic pressure gradient. Results: Aortic valve calcification area was significantly higher in PHPT (0.24 ± 0.02 vs. 0.17 ± 0.02 cm 2, p<0.01), although there was no difference in the peak transaortic pressure gradient, a functional measure of valvular calcification (5.6 ± 0.3 vs. 6.0 ± 0.3 mm Hg, P = 0.39). Aortic valve calcification area was positively associated with PTH (r=0.34; P<0.05) but not with serum calcium, phosphorus, or 25-hydroxyvitamin D levels or with calcium-phosphate product. Serum PTH level remained an independent predictor of aortic valve calcification area after adjustment for age, sex, bodymass index,smokingstatus, history of hypercholesterolemiaandhypertension,andestimated glomerular filtration rate. Conclusions: Mild PHPT is associated with subclinical aortic valve calcification. PTH, but not serum calcium concentration, predicted aortic valve calcification. PTH was a more important predictor of aortic valve calcification than well-accepted cardiovascular risk factors.

Original languageEnglish (US)
Pages (from-to)132-137
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Issue number1
StatePublished - Jan 2012

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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