Anxiolytics: Past, present, and future agents

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Although anxiety disorders were classified as neurotic disorders and not systematically studied before DSM-III, researchers and clinicians have been searching for effective, safe agents to treat anxiety symptoms and disorders for over a century. In that time, barbiturates, benzodiazepines, and many classes of antidepressants have been used as anxiolytics, all with side effect profiles that made them less than optimal treatments for anxiety. The recognition of the role of GABA in anxiety disorders has led researchers to develop anxiolytics that target GABA. The long-sought-after class of anxiolytics that are both effective and safe may be found in the new research being conducted with agents that selectively target GABA receptors and their subtypes.

Original languageEnglish
Pages (from-to)3-6
Number of pages4
JournalJournal of Clinical Psychiatry
Volume64
Issue numberSUPPL. 3
StatePublished - Apr 12 2003
Externally publishedYes

Fingerprint

Anti-Anxiety Agents
Anxiety Disorders
gamma-Aminobutyric Acid
Research Personnel
Barbiturates
GABA Receptors
Neurotic Disorders
Benzodiazepines
Diagnostic and Statistical Manual of Mental Disorders
Antidepressive Agents
Anxiety
Research

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Anxiolytics : Past, present, and future agents. / Nemeroff, Charles.

In: Journal of Clinical Psychiatry, Vol. 64, No. SUPPL. 3, 12.04.2003, p. 3-6.

Research output: Contribution to journalArticle

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