Abstract
The effects of LV in two different species, CD-1 mice, without a genetic disposition for diabetes, and BB rats prone to T1D were examined. Male CD-1 mice that had been exposed toLV in utero developed a type 2-like diabetes with increased blood glucose, insulin levels and epididymal fat at the age of 10-15 weeks. Combination therapy including LV-antiserum and an antiviral drug, Pleconaril, significantly reduced the levels of blood glucose and insulin and the amount of abdominal fat. In BB rats, LV has been found in both prediabetic- and diabetic diabetes-prone rats, as well as in diabetes-resistant rats. To evaluate whether the presence of LV has any influence on the onset of T1D, prediabetic BB rats were treated with an antiserum against LV or a combination of the antiviral drugs Pleconaril and Ribavirin. In the group treated with antiviral drugs, the onset was significantly delayed. These results indicate that the presence of LV can be involved in the pathogenesis of diabetes in these animal models.
| Original language | English |
|---|---|
| Pages (from-to) | 567-572 |
| Number of pages | 6 |
| Journal | Microbiology and Immunology |
| Volume | 53 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2009 |
| Externally published | Yes |
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Keywords
- Antibody treatment
- Antiviral therapy
- Viral infection
ASJC Scopus subject areas
- Immunology
- Microbiology
- Virology
Cite this
Antiviral treatments reduce severity of diabetes in Ljungan virus-infected CD-1 mice and delay onset in diabetes-prone BB rats. / Holmberg, Rebecka; Klitz, William; Blixt, Martin; Berggren, Per Olof; Juntti-Berggren, Lisa; Niklasson, Bo.
In: Microbiology and Immunology, Vol. 53, No. 10, 01.10.2009, p. 567-572.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antiviral treatments reduce severity of diabetes in Ljungan virus-infected CD-1 mice and delay onset in diabetes-prone BB rats
AU - Holmberg, Rebecka
AU - Klitz, William
AU - Blixt, Martin
AU - Berggren, Per Olof
AU - Juntti-Berggren, Lisa
AU - Niklasson, Bo
PY - 2009/10/1
Y1 - 2009/10/1
N2 - The effects of LV in two different species, CD-1 mice, without a genetic disposition for diabetes, and BB rats prone to T1D were examined. Male CD-1 mice that had been exposed toLV in utero developed a type 2-like diabetes with increased blood glucose, insulin levels and epididymal fat at the age of 10-15 weeks. Combination therapy including LV-antiserum and an antiviral drug, Pleconaril, significantly reduced the levels of blood glucose and insulin and the amount of abdominal fat. In BB rats, LV has been found in both prediabetic- and diabetic diabetes-prone rats, as well as in diabetes-resistant rats. To evaluate whether the presence of LV has any influence on the onset of T1D, prediabetic BB rats were treated with an antiserum against LV or a combination of the antiviral drugs Pleconaril and Ribavirin. In the group treated with antiviral drugs, the onset was significantly delayed. These results indicate that the presence of LV can be involved in the pathogenesis of diabetes in these animal models.
AB - The effects of LV in two different species, CD-1 mice, without a genetic disposition for diabetes, and BB rats prone to T1D were examined. Male CD-1 mice that had been exposed toLV in utero developed a type 2-like diabetes with increased blood glucose, insulin levels and epididymal fat at the age of 10-15 weeks. Combination therapy including LV-antiserum and an antiviral drug, Pleconaril, significantly reduced the levels of blood glucose and insulin and the amount of abdominal fat. In BB rats, LV has been found in both prediabetic- and diabetic diabetes-prone rats, as well as in diabetes-resistant rats. To evaluate whether the presence of LV has any influence on the onset of T1D, prediabetic BB rats were treated with an antiserum against LV or a combination of the antiviral drugs Pleconaril and Ribavirin. In the group treated with antiviral drugs, the onset was significantly delayed. These results indicate that the presence of LV can be involved in the pathogenesis of diabetes in these animal models.
KW - Antibody treatment
KW - Antiviral therapy
KW - Viral infection
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UR - http://www.scopus.com/inward/citedby.url?scp=73349083391&partnerID=8YFLogxK
U2 - 10.1111/j.1348-0421.2009.00160.x
DO - 10.1111/j.1348-0421.2009.00160.x
M3 - Article
C2 - 19780970
AN - SCOPUS:73349083391
VL - 53
SP - 567
EP - 572
JO - Microbiology and Immunology
JF - Microbiology and Immunology
SN - 0385-5600
IS - 10
ER -