Antitumorigenic effect of brain proline rich polypeptide-1 in human chondrosarcoma

Karina Galoian, Sean Scully, George McNamara, Patrick Flynn, Armen Galoyan

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Proline rich polypeptide (PRP-1) produced by neurosecretory cells of the hypothalamus is one of the fragments of neurophysin-vasopressin-associated glycoprotein. The primary structure of the neuropeptide PRP-1 isolated from neurosecretory granules of bovine neurohypophysis. We investigated PRP-1 action on chondrosarcoma, the second most common malignancy in bone, which primarily affects the cartilage cells. This deadly disease does not have any effective treatment. Earlier we demonstrated MYC oncogene inactivating effect by 1 μg/ml concentration brain PRP-1 In the present study we observed reduced viable sarcoma JJ012 cell numbers in comparison with control (89% growth inhibition) when treated with low concentrations of PRP-1 (0.5-1 μg/ml). Higher concentrations did not exhibit inhibitory effect. We assume that PRP-1 in low concentration impedes cell cycle progression. The fact that low concentrations of PRP-1 abolished Myc activity prompts to think that the antitumorigenic effect of PRP-1 in low concentrations is mediated through oncogene inactivation.

Original languageEnglish (US)
Pages (from-to)2117-2121
Number of pages5
JournalNeurochemical Research
Volume34
Issue number12
DOIs
StatePublished - Dec 1 2009

Keywords

  • Cell cycle
  • Chondrosarcoma
  • CMyc
  • Hypothalamus
  • Proline rich polypeptide-1

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Biochemistry

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