Antithyroid antibodies in depressed patients

C. B. Nemeroff, J. S. Simon, J. J. Haggerty, D. L. Evans

Research output: Contribution to journalArticlepeer-review

94 Scopus citations


The presence of antithyroid (antimicrosomal and antithyroglobulin) antibodies was assessed in 45 psychiatric inpatients with prominent depressive symptoms (28 with DSM-III major depression). Nine patients (20%) had detectable titers of antithyroid antibodies, a rate considerably higher than the 5%-10% observed in the normal population. Each of these nine patients with symptomless autoimmune thyroiditis had normal baseline serum thyrotropin concentrations and normal thyroid function (as assessed by T4, T3 uptake, and free thyroxine index). These findings support the hypothesis of subtle thyroid dysfunction in a sizable sample of psychiatric inpatients with prominent depressive symptoms.

Original languageEnglish (US)
Pages (from-to)840-843
Number of pages4
JournalAmerican Journal of Psychiatry
Issue number7
StatePublished - Jan 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health


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