Antiserum to LH-RH blocks haloperidol-induced hyperprolactinemia in female rats

L. Debeljuk, I. Torres-Aleman, Andrew V Schally

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We investigated the effect of blocking endogenous LH-RH, by injection of anti LH-RH sera, on serum prolactin levels previously elevated by treatment with haloperidol for 5 days. An acute intravenous injection of rabbit anti-LH-RH serum significantly reduced serum LH levels and blocked the hyperprolactinemia induced by haloperidol. In another group of rats, sheep anti-LH-RH serum induced a significant decrease of serum LH and also lowered serum prolactin levels previously elevated by haloperidol. In ovariectomized rats, sheep anti-LH-RH serum markedly reduced serum LH levels and also decreased serum prolactin elevated by the pretreatment with haloperidol. It is concluded that the serum LH levels and also decreased serum prolactin elevated by the pretreatment with haloperidol. It is concluded that the blocking of endogenous LH-RH action resulted in a decreased release of prolactin in response to stimuli like haloperidol. These results support the possible existence of a paracrine interaction between the pituitary gonadotrophs and lactotrophs.

Original languageEnglish
Pages (from-to)185-187
Number of pages3
JournalNeuroendocrinology
Volume40
Issue number2
StatePublished - Jan 1 1985
Externally publishedYes

Fingerprint

Hyperprolactinemia
Haloperidol
Gonadotropin-Releasing Hormone
Immune Sera
Serum
Prolactin
Sheep
Lactotrophs
Gonadotrophs
Intravenous Injections

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Cite this

Antiserum to LH-RH blocks haloperidol-induced hyperprolactinemia in female rats. / Debeljuk, L.; Torres-Aleman, I.; Schally, Andrew V.

In: Neuroendocrinology, Vol. 40, No. 2, 01.01.1985, p. 185-187.

Research output: Contribution to journalArticle

Debeljuk, L. ; Torres-Aleman, I. ; Schally, Andrew V. / Antiserum to LH-RH blocks haloperidol-induced hyperprolactinemia in female rats. In: Neuroendocrinology. 1985 ; Vol. 40, No. 2. pp. 185-187.
@article{7338effb337f4586924e0500e48a1765,
title = "Antiserum to LH-RH blocks haloperidol-induced hyperprolactinemia in female rats",
abstract = "We investigated the effect of blocking endogenous LH-RH, by injection of anti LH-RH sera, on serum prolactin levels previously elevated by treatment with haloperidol for 5 days. An acute intravenous injection of rabbit anti-LH-RH serum significantly reduced serum LH levels and blocked the hyperprolactinemia induced by haloperidol. In another group of rats, sheep anti-LH-RH serum induced a significant decrease of serum LH and also lowered serum prolactin levels previously elevated by haloperidol. In ovariectomized rats, sheep anti-LH-RH serum markedly reduced serum LH levels and also decreased serum prolactin elevated by the pretreatment with haloperidol. It is concluded that the serum LH levels and also decreased serum prolactin elevated by the pretreatment with haloperidol. It is concluded that the blocking of endogenous LH-RH action resulted in a decreased release of prolactin in response to stimuli like haloperidol. These results support the possible existence of a paracrine interaction between the pituitary gonadotrophs and lactotrophs.",
author = "L. Debeljuk and I. Torres-Aleman and Schally, {Andrew V}",
year = "1985",
month = "1",
day = "1",
language = "English",
volume = "40",
pages = "185--187",
journal = "Neuroendocrinology",
issn = "0028-3835",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Antiserum to LH-RH blocks haloperidol-induced hyperprolactinemia in female rats

AU - Debeljuk, L.

AU - Torres-Aleman, I.

AU - Schally, Andrew V

PY - 1985/1/1

Y1 - 1985/1/1

N2 - We investigated the effect of blocking endogenous LH-RH, by injection of anti LH-RH sera, on serum prolactin levels previously elevated by treatment with haloperidol for 5 days. An acute intravenous injection of rabbit anti-LH-RH serum significantly reduced serum LH levels and blocked the hyperprolactinemia induced by haloperidol. In another group of rats, sheep anti-LH-RH serum induced a significant decrease of serum LH and also lowered serum prolactin levels previously elevated by haloperidol. In ovariectomized rats, sheep anti-LH-RH serum markedly reduced serum LH levels and also decreased serum prolactin elevated by the pretreatment with haloperidol. It is concluded that the serum LH levels and also decreased serum prolactin elevated by the pretreatment with haloperidol. It is concluded that the blocking of endogenous LH-RH action resulted in a decreased release of prolactin in response to stimuli like haloperidol. These results support the possible existence of a paracrine interaction between the pituitary gonadotrophs and lactotrophs.

AB - We investigated the effect of blocking endogenous LH-RH, by injection of anti LH-RH sera, on serum prolactin levels previously elevated by treatment with haloperidol for 5 days. An acute intravenous injection of rabbit anti-LH-RH serum significantly reduced serum LH levels and blocked the hyperprolactinemia induced by haloperidol. In another group of rats, sheep anti-LH-RH serum induced a significant decrease of serum LH and also lowered serum prolactin levels previously elevated by haloperidol. In ovariectomized rats, sheep anti-LH-RH serum markedly reduced serum LH levels and also decreased serum prolactin elevated by the pretreatment with haloperidol. It is concluded that the serum LH levels and also decreased serum prolactin elevated by the pretreatment with haloperidol. It is concluded that the blocking of endogenous LH-RH action resulted in a decreased release of prolactin in response to stimuli like haloperidol. These results support the possible existence of a paracrine interaction between the pituitary gonadotrophs and lactotrophs.

UR - http://www.scopus.com/inward/record.url?scp=0021990727&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021990727&partnerID=8YFLogxK

M3 - Article

VL - 40

SP - 185

EP - 187

JO - Neuroendocrinology

JF - Neuroendocrinology

SN - 0028-3835

IS - 2

ER -