Antiserum to LH-RH blocks haloperidol-induced hyperprolactinemia in female rats

Luciano Debeljuk, Ignacio Torres-Aleman, Andrew V. Schally

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

We investigated the effect of blocking endogenous LH-RH, by injection of anti LH-RH sera, on serum prolactin levels previously elevated by treatment with haloperidol for 5 days. An acute intravenous injection of rabbit anti-LH-RH serum significantly reduced serum LH levels and blocked the hyperprolactinemia induced by haloperidol. In another group of rats, sheep anti-LH-RH serum induced a significant decrease of serum LH and also lowered serum prolactin levels previously elevated by haloperidol. In ovariectomized rats, sheep anti-LH-RH serum markedly reduced serum LH levels and also decreased serum prolactin elevated by the pretreatment with haloperidol. It is concluded that the serum LH levels and also decreased serum prolactin elevated by the pretreatment with haloperidol. It is concluded that the blocking of endogenous LH-RH action resulted in a decreased release of prolactin in response to stimuli like haloperidol. These results support the possible existence of a paracrine interaction between the pituitary gonadotrophs and lactotrophs.

Original languageEnglish (US)
Pages (from-to)185-187
Number of pages3
JournalNeuroendocrinology
Volume40
Issue number2
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

Keywords

  • Anti-LH-RH serum
  • Haloperidol
  • Luteinizing hormone-releasing hormone
  • Pituitary
  • Prolactin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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