TY - JOUR
T1 - Antiseptics on wounds
T2 - An area of controversy
AU - Drosou, Anna
AU - Falabella, Anna
AU - Kirsner, Robert S.
PY - 2003/5
Y1 - 2003/5
N2 - Antiseptics have long and commonly been used on wounds to prevent or treat infection. However, citing cytotoxicity data, many authors have advised against their use on open wounds. This article discusses antiseptics and their use on open wounds, as well reviews relevant animal studies and clinical trials examining the effects of commonly used antiseptics, including iodine compounds (povidone iodine and cadexomer iodine), chlorhexidine, hydrogen peroxide, acetic acid, and silver compounds. This article examines their effects on wound healing and reepithelization and their efficacy on reducing bacterial number in wounds and incidence of wound infections. The authors found despite cytotoxicty data, most antiseptics have not been shown to clearly impede healing, especially newer formulations like cadexomer iodine (which speeds healing) and novel silver delivery systems. These compounds appear to be relatively safe and efficient in preventing infection in human wounds. Given this review, the role of antiseptics on wounds and their role in wound care management should be reconsidered.
AB - Antiseptics have long and commonly been used on wounds to prevent or treat infection. However, citing cytotoxicity data, many authors have advised against their use on open wounds. This article discusses antiseptics and their use on open wounds, as well reviews relevant animal studies and clinical trials examining the effects of commonly used antiseptics, including iodine compounds (povidone iodine and cadexomer iodine), chlorhexidine, hydrogen peroxide, acetic acid, and silver compounds. This article examines their effects on wound healing and reepithelization and their efficacy on reducing bacterial number in wounds and incidence of wound infections. The authors found despite cytotoxicty data, most antiseptics have not been shown to clearly impede healing, especially newer formulations like cadexomer iodine (which speeds healing) and novel silver delivery systems. These compounds appear to be relatively safe and efficient in preventing infection in human wounds. Given this review, the role of antiseptics on wounds and their role in wound care management should be reconsidered.
UR - http://www.scopus.com/inward/record.url?scp=0037660764&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037660764&partnerID=8YFLogxK
M3 - Review article
AN - SCOPUS:0037660764
VL - 15
SP - 149
EP - 166
JO - Wounds
JF - Wounds
SN - 1044-7946
IS - 5
ER -