Antisense RNA therapy for CML - An hypothesis

K. S. Nadkarni, R. H. Datar, S. G. Ananda Rao

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CML, a myeloproliferative clonal disorder of myeloid stem cells, is characterized by the consistent presence of a bcr - c-abl fusion gene which is formed as a rsult of a translocation of the c-abl gene from chromosome 9 to downstream of the bcr gene on chromosome 22 (ph'). Current approaches to the treatment of CML are chemotherapy (conventional or aggressive with immuno-modulators) and bone marrow transplantation (BMT). Neither of the abve treatment modalities results in long-term remission or cure. Hence, an alternative approach which aims at correcting the genetic defect should be considered. Taking advantage of the consistent abnormal presence of the bcr - c-abl gene in the treated and untreated CML patients at all stages, a gene therapy at the level of blocking mRNA might be considered. Such an antisense RNA therapy should include removal of patient's bone marrow, administration of the gene for constitutive expression of an antisense RNA for the bcr - c-abl fusion gene into the myeloid stem cells and reinjecting the engineered marrow into the patient. Such an approach, comparable to autologous BMT, will have the advantages of absence of graft rejection and possibility of 100% remission. The possible nature of the gene construct for such an antisense RNA therapy is discussed.

Original languageEnglish (US)
Pages (from-to)307-310
Number of pages4
JournalMedical Hypotheses
Issue number4
StatePublished - Aug 1991

ASJC Scopus subject areas

  • Medicine(all)


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