Antiproliferative activity of taxol on human tumor and normal breast cells vs. effects on cardiac cells

DaniéLe Brouty‐Boye, Dcspina Kolonias, Theodore J. Lampidis

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The antiproliferative activity of the chemotherapeutic agent taxol was evaluated on 2 normal and 2 carcinoma human breast-cell lines and compared with its effects on newborn rat cardiac cells growing in vitro. Relatively little difference in IDS50, response (ranging from 0.6 to 2.0 ng/ml) to taxol was found between normal and tumorous breast epithelial cells. Arrhythmias and slowing of beat frequencies of cardiac cells were induced by taxol but at doses approximately 10 times higher than those necessary to inhibit proliferation in dividing cells. Microtubules assayed by immunostaining appeared to be similarly retracted around the nucleus in both breast and heart cells. Overall, our results suggest that taxol does not selectively inhibit the growth of tumor vs. normal human breast cells. They also support the hypothesis that effects on microtubule integrity are associated with effects on cardiac function and that the clinical cardiac activity of taxol already reported may be due, at least in part, to a direct effect of taxol on cardiac cells as demonstrated in these in vitro studies. Thus, caution is needed, in view of possible cardiac effects, when using taxol in future clinical protocols, especially when combined with other cardioactive agents such as Adriamycin.

Original languageEnglish (US)
Pages (from-to)571-575
Number of pages5
JournalInternational Journal of Cancer
Volume60
Issue number4
DOIs
StatePublished - Feb 8 1995

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Antiproliferative activity of taxol on human tumor and normal breast cells vs. effects on cardiac cells'. Together they form a unique fingerprint.

Cite this