Abstract
Objectives: This is a critical review of anti-phospholipid antibodies (aPL). Most prior reviews focus on the aPL syndrome (APS), a thrombotic condition often marked by neurological disturbance. We bring to attention recent evidence that aPL may be equally relevant to non-thrombotic autoimmune conditions, notably, multiple sclerosis and ITP. Organization: After a brief history, the recent proliferation of aPL target antigens is reviewed. The implication is that many more exist. Theories of aPL in thrombosis are then reviewed, concluding that all have merit but that aPL may have more diverse pathological consequences than now recognized. Next, conflicting results are explained by methodological differences. The lupus anticoagulant (LA) is then discussed. LA is the best predictor of thrombosis, but why this is true is not settled. Finally, aPL in non-thrombotic disorders is reviewed. Conclusion: The current paradigm of aPL holds that they are important in thrombosis, but they may have much wider clinical significance, possibly of special interest in neurology.
| Original language | English |
|---|---|
| Article number | 3 |
| Journal | Journal of Neuroinflammation |
| Volume | 6 |
| DOIs | |
| State | Published - Jan 20 2009 |
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ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Neurology
- Immunology
- Neuroscience(all)
Cite this
Antiphospholipid antibodies : Paradigm in transition. / Horstman, Lawrence L.; Jy, Wenche; Bidot, Carlos J.; Ahn, Yeon; Kelley, Roger E.; Zivadinov, Robert; Maghzi, Amir H.; Etemadifar, Masoud; Mousavi, Seyed Ali; Minagar, Alireza.
In: Journal of Neuroinflammation, Vol. 6, 3, 20.01.2009.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antiphospholipid antibodies
T2 - Paradigm in transition
AU - Horstman, Lawrence L.
AU - Jy, Wenche
AU - Bidot, Carlos J.
AU - Ahn, Yeon
AU - Kelley, Roger E.
AU - Zivadinov, Robert
AU - Maghzi, Amir H.
AU - Etemadifar, Masoud
AU - Mousavi, Seyed Ali
AU - Minagar, Alireza
PY - 2009/1/20
Y1 - 2009/1/20
N2 - Objectives: This is a critical review of anti-phospholipid antibodies (aPL). Most prior reviews focus on the aPL syndrome (APS), a thrombotic condition often marked by neurological disturbance. We bring to attention recent evidence that aPL may be equally relevant to non-thrombotic autoimmune conditions, notably, multiple sclerosis and ITP. Organization: After a brief history, the recent proliferation of aPL target antigens is reviewed. The implication is that many more exist. Theories of aPL in thrombosis are then reviewed, concluding that all have merit but that aPL may have more diverse pathological consequences than now recognized. Next, conflicting results are explained by methodological differences. The lupus anticoagulant (LA) is then discussed. LA is the best predictor of thrombosis, but why this is true is not settled. Finally, aPL in non-thrombotic disorders is reviewed. Conclusion: The current paradigm of aPL holds that they are important in thrombosis, but they may have much wider clinical significance, possibly of special interest in neurology.
AB - Objectives: This is a critical review of anti-phospholipid antibodies (aPL). Most prior reviews focus on the aPL syndrome (APS), a thrombotic condition often marked by neurological disturbance. We bring to attention recent evidence that aPL may be equally relevant to non-thrombotic autoimmune conditions, notably, multiple sclerosis and ITP. Organization: After a brief history, the recent proliferation of aPL target antigens is reviewed. The implication is that many more exist. Theories of aPL in thrombosis are then reviewed, concluding that all have merit but that aPL may have more diverse pathological consequences than now recognized. Next, conflicting results are explained by methodological differences. The lupus anticoagulant (LA) is then discussed. LA is the best predictor of thrombosis, but why this is true is not settled. Finally, aPL in non-thrombotic disorders is reviewed. Conclusion: The current paradigm of aPL holds that they are important in thrombosis, but they may have much wider clinical significance, possibly of special interest in neurology.
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UR - http://www.scopus.com/inward/citedby.url?scp=60849110567&partnerID=8YFLogxK
U2 - 10.1186/1742-2094-6-3
DO - 10.1186/1742-2094-6-3
M3 - Article
C2 - 19154576
AN - SCOPUS:60849110567
VL - 6
JO - Journal of Neuroinflammation
JF - Journal of Neuroinflammation
SN - 1742-2094
M1 - 3
ER -