Antiphospholipid antibodies and pregnancy outcomes in women heterozygous for Factor V Leiden

Tracy Manuck, D. Ware Branch, Yinglei Lai, Baha Sibai, Catherine Y. Spong, George Wendel, Katharine Wenstrom, Philip Samuels, Steve N. Caritis, Yoram Sorokin, Menachem Miodovnik, Mary J. O'sullivan, Deborah Conway, Ronald J. Wapner

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Antiphospholipid antibodies are associated with a spectrum of pregnancy complications, including preeclampsia and small for gestational age (SGA) fetuses. We sought to assess anticardiolipin and anti-β2-glycoprotein I (anti-β2-GPI) IgG and IgM antibody prevalence and the relationship of these antibodies to pregnancy complications in women with the Factor V Leiden (FVL) mutation. The study comprised a secondary analysis of a multicenter, prospective observational study of FVL prevalence among 5188 asymptomatic pregnant women. A subset of 362 women (117 FVL heterozygotes, 245 matched controls) had serum collected at the time of the original study and underwent serum analysis for anticardiolipin and anti-β2-GPI IgG and IgM as a part of this analysis. The primary outcome was preeclampsia and/or SGA (<10%). The overall prevalence of anticardiolipin and anti-β2-GPI IgG and IgM antibodies was low and did not vary with FVL status. Forty-seven women (13.0%) developed preeclampsia and/or SGA. There were no differences in primary outcome rates between women with and without aPL antibodies, regardless of FVL mutation status. Among FVL carriers, the presence of antiphospholipid antibodies does not appear to contribute to adverse pregnancy outcome.

Original languageEnglish
Pages (from-to)180-185
Number of pages6
JournalJournal of Reproductive Immunology
Volume85
Issue number2
DOIs
StatePublished - Jun 1 2010
Externally publishedYes

Fingerprint

Antiphospholipid Antibodies
Pregnancy Outcome
Pre-Eclampsia
Gestational Age
Immunoglobulin M
Glycoproteins
Pregnancy Complications
Antibodies
Immunoglobulin G
Mutation
Heterozygote
Serum
Observational Studies
factor V Leiden
Pregnant Women
Fetus
Prospective Studies

Keywords

  • Antiphospholipid antibodies
  • Factor V Leiden
  • Preeclampsia
  • Small for gestational age

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Manuck, T., Branch, D. W., Lai, Y., Sibai, B., Spong, C. Y., Wendel, G., ... Wapner, R. J. (2010). Antiphospholipid antibodies and pregnancy outcomes in women heterozygous for Factor V Leiden. Journal of Reproductive Immunology, 85(2), 180-185. https://doi.org/10.1016/j.jri.2010.03.007

Antiphospholipid antibodies and pregnancy outcomes in women heterozygous for Factor V Leiden. / Manuck, Tracy; Branch, D. Ware; Lai, Yinglei; Sibai, Baha; Spong, Catherine Y.; Wendel, George; Wenstrom, Katharine; Samuels, Philip; Caritis, Steve N.; Sorokin, Yoram; Miodovnik, Menachem; O'sullivan, Mary J.; Conway, Deborah; Wapner, Ronald J.

In: Journal of Reproductive Immunology, Vol. 85, No. 2, 01.06.2010, p. 180-185.

Research output: Contribution to journalArticle

Manuck, T, Branch, DW, Lai, Y, Sibai, B, Spong, CY, Wendel, G, Wenstrom, K, Samuels, P, Caritis, SN, Sorokin, Y, Miodovnik, M, O'sullivan, MJ, Conway, D & Wapner, RJ 2010, 'Antiphospholipid antibodies and pregnancy outcomes in women heterozygous for Factor V Leiden', Journal of Reproductive Immunology, vol. 85, no. 2, pp. 180-185. https://doi.org/10.1016/j.jri.2010.03.007
Manuck, Tracy ; Branch, D. Ware ; Lai, Yinglei ; Sibai, Baha ; Spong, Catherine Y. ; Wendel, George ; Wenstrom, Katharine ; Samuels, Philip ; Caritis, Steve N. ; Sorokin, Yoram ; Miodovnik, Menachem ; O'sullivan, Mary J. ; Conway, Deborah ; Wapner, Ronald J. / Antiphospholipid antibodies and pregnancy outcomes in women heterozygous for Factor V Leiden. In: Journal of Reproductive Immunology. 2010 ; Vol. 85, No. 2. pp. 180-185.
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